摘要
放疗是恶性肿瘤治疗的重要手段。放疗抵抗是影响放疗疗效的主要障碍。细胞代谢重编程是癌症的主要特征之一,对放疗疗效可能产生重要的影响。谷氨酰胺与肿瘤细胞生物合成和生长密切相关,并通过分解产生抗氧化剂影响放疗敏感度。另外,谷氨酰胺的两种同工酶谷氨酰胺酶(GLS)和谷氨酰胺酶2(GLS2)的表达和功能不同,对放疗敏感度存在重要影响。利用肿瘤微环境中的谷氨酰胺代谢来提高放疗疗效具有重要的研究价值。本文主要综述恶性肿瘤的谷氨酰胺代谢特征以及谷氨酰胺酶抑制剂对放疗的增敏效应。
Radiotherapy is an important treatment method for malignant tumors.Radiation resistance is the main obstacle to the therapeutic effect of radiotherapy.Cellular metabolic reprogramming is one of the main features of cancer,and it may have an important effect on the therapeutic effect of radiotherapy.Glutamine is closely related to tumor cell biosynthesis and growth.It affects radiotherapy sensitivity by producing antioxidants through decomposition.In addition,the expression patterns and functions of two isoenzymes of glutamine,namely,glutaminase(GLS)and glutaminase 2(GLS2),are different and have an important influence on the sensitivity of radiotherapy.The utilization of glutamine metabolism in the tumor microenvironment has great research value to improve the efficacy of radiotherapy.This review describes the metabolic characteristics of glutamine in malignant tumors and the sensitization effect of glutamine inhibitors on the efficacy of radiotherapy.
作者
乔万佳
董娜
刘小军
QIAO Wanjia;DONG Na;LIU Xiaojun(The First School of Clinical Medicine,Lanzhou University,Lanzhou 730000,China;Department of Radiotherapy,Gansu Provincial People’s Hospital,Lanzhou 730000,China)
出处
《肿瘤防治研究》
CAS
2023年第3期298-302,共5页
Cancer Research on Prevention and Treatment
基金
甘肃省自然科学基金(21JR7RA618)。
作者简介
乔万佳(1996-),女,硕士在读,主要从事恶性肿瘤放疗及免疫治疗研究;通信作者:刘小军(1976-),男,博士,副主任医师,主要从事恶性肿瘤放疗及免疫治疗研究,E-mail:lxjmail2008@126.com。
