摘要
目的 分析宫腔镜冷刀切除子宫肌瘤对患者子宫内膜容受性及血清肿瘤坏死因子-α(TNF-α)、白介素-1β(IL-1β)、白介素-6(IL-6)水平的影响。方法 选取2019年7月至2021年6月收治的子宫肌瘤患者40例作为研究对象,依据简单数字表法将其随机分为对照组和观察组,每组40例。对照组行腹腔镜手术治疗,观察组行宫腔镜冷刀去除术治疗。比较2组肌层愈合情况、手术相关指标、子宫内膜容受性(子宫内膜厚度、子宫内膜血流博动指数、阻力指数)、炎性因子水平(TNF-α、IL-1β、IL-6)、并发症情况。结果 术后1~6个月2组肌层愈合率均逐渐升高,且观察组高于对照组(P<0.05)。相较于对照组,观察组手术时间、首次下床活动时间、术后肛门排气时间、住院时间均明显缩短,术中出血量明显减少(P<0.05)。相较于术前,1个月时2组子宫内膜厚度均升高,并且观察组高于对照组;而2组子宫内膜血流搏动指数及阻力指数均降低,并且观察组低于对照组(P<0.05)。相较于术前,术后3 d2组TNF-α、IL-1β、IL-6均升高,但观察组低于对照组(P<0.05)。2组并发症比较差异无统计学意义(P>0.05)。结论 相较于腹腔镜手术,宫腔镜冷刀去除子宫肌瘤的疗效更加显著,不仅有利于肌层愈合,还能够保障子宫内膜容受性,同时有效减轻手术对机体造成的炎性损伤,促进患者术后恢复。
Objective To analyze the effect of hysteroscopic cold knife resection of uterine fibroids(UF) on endometrial receptivity and expression levels of serum tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β),and interleukin-6(IL-6).Methods A total of 40 DF patients treated in our hospital from July 2019 to June 2021 were retrospectively recruited.They were randomized 1∶1 to receive laparoscopic operation(the control group) or hysteroscopic cold knife resection(the observation group).The myometrial healing,surgery-related indicators,endometrial receptivity(endometrial thickness,pulsatility index and resistance index),inflammatory factor levels(TNF-α,IL-1β and IL-6),and complications were compared between the two groups.Results From 1 to 6 months after the operation,the healing rate of the muscle layer in the two groups gradually increased,which was significantly higher in the observation group than in the control group(P<0.05).Compared with the control group,the operation time,first ambulation time,postoperative anal exhaust time,and hospital stay in the observation group were significantly shortened,and the intraoperative blood loss was significantly reduced(P<0.05).Compared with those before operation,the endometrial thickness of the two groups increased at 1 month,which was significantly higher in the observation group than in the control group.On the contrary,pulsatility index and resistance index were reduced in both groups,which were significantly pronounced in the observation group(P<0.05).Compared with those before operation,the expression levels of TNF-α,IL-1β and IL-6 in both groups were enhanced on day 3,which were significantly lower in the observation group than those in control group(P<0.05).There was no significant difference in the complications between the two groups(P>0.05).Conclusion Compared with laparoscopic surgery,the therapeutic efficacy of hysteroscopic cold knife resection of uterine fibroids is more superior.It is not only conducive to the healing of the myometrium,but also ensure the receptivity of the endometrium,and effectively reduce surgery-induced inflammation.It significantly promotes the postoperative recovery.
作者
王渝琦
胡远飞
WANG Yuqi;HU Yuanfei(Department of Obstetrics and Gynecology,People’s Hospital of Yubei District,Chongqing 401120,China)
出处
《河北医药》
CAS
2023年第2期259-262,共4页
Hebei Medical Journal
作者简介
通讯作者:胡远飞,E-mail:17623857427@sina.com。
