摘要
目的探讨出生时胎龄<32周早产儿生后早期动脉血胎儿血红蛋白(HbF)水平与早产儿视网膜病(retinopathy of prematurity,ROP)发病的关系。方法选择2019年3月—2022年2月我院新生儿科收治的出生时胎龄<32周的早产儿99例,根据是否诊断为ROP,分为ROP组(34例)和非ROP组(65例)。比较两组患儿的临床资料,采用Logistic回归法分析患儿生后2周动脉血HbF水平与ROP的相关性。结果ROP组患儿出生时胎龄以及出生体质量均显著低于非ROP组(t=3.371、3.218,P<0.05),出生时胎龄<28周患儿构成比、出生体质量<1000 g患儿构成比、顺产患儿构成比、生后2周内输血患儿构成比,以及用氧时间与住院时间均显著高于或长于非ROP组(χ^(2)=4.390~11.579,Z=3.283、5.207,P<0.05)。ROP组患儿生后2周动脉血血红蛋白(Hb)水平及HbF比例均显著低于非ROP组(t=-2.791、-3.599,P<0.05)。Logistic回归法分析显示,动脉血HbF比例降低是ROP发生的危险因素(OR=0.915,95%CI=0.849~0.987,P<0.05)。结论出生时胎龄<32周早产儿生后2周动脉血HbF比例降低是ROP发生的危险因素,维持较高的动脉血HbF水平可能对临床ROP的发生具有预防作用。
Objective To investigate the association between fetal hemoglobin(HbF)level in arterial blood early after birth and the onset of retinopathy of prematurity(ROP)in preterm infants with a gestational age of<32 weeks.Methods A total of 99 preterm infants with a gestational age of<32 weeks who were admitted to Department of Neonatology in our hospital from March 2019 to February 2022 were enrolled,and according to whether they were diagnosed with ROP,they were divided into ROP group with 34 infants and non-ROP group with 65 infants.Clinical data were compared between the two groups,and the logistic regression method was used to investigate the association between HbF level in arterial blood and ROP at 2 weeks after birth.Results Compared with the non-ROP group,the ROP group had significantly lower gestational age and birth weight(t=3.371,3.218,P<0.05),significantly higher constituent ratios of infants with a gestational age of<28 weeks,infants with a birth weight of<1000 g,infants born by vaginal delivery,and infants receiving blood transfusion within 2 weeks after birth,and significantly longer oxygen supply time and length of hospital stay(χ^(2)=4.390-11.579,Z=3.283,5.207,P<0.05).Compared with the non-ROP group,the ROP group had significantly lower hemoglobin level and HbF ratio in arterial blood at 2 weeks after birth(t=-2.791,-3.599,P<0.05).The logistic regression analysis showed that the reduction in HbF ratio in arterial blood was a risk factor for ROP(OR=0.915,95%CI=0.849-0.987,P<0.05).Conclusion The reduction in HbF ratio in arterial blood at 2 weeks after birth is a risk factor for ROP in preterm infants with a gestational age of<32 weeks,and maintaining a high HbF level in arterial blood may have a preventive effect on ROP.
作者
卫红利
张璐璐
孙梦雅
徐彤
赖春池
姜红
WEI Hongli;ZHANG Lulu;SUN Mengya;XU Tong;LAI Chunchi;JIANG Hong(Neonatal Department,The Affiliated Hospital of Qingdao University,Qingdao 266003,China)
出处
《精准医学杂志》
2023年第1期28-31,共4页
Journal of Precision Medicine
基金
山东省中医药科技发展计划项目(2019-0402)。
关键词
胎儿血红蛋白
早产儿视网膜病
婴儿
早产
Fetal hemoglobin
Retinopathy of prematurity
Infant,premature
作者简介
通讯作者:姜红,Email:jianghongbs@163.com。
