摘要
目的 比较吲哚菁绿(ICG)荧光腹腔镜与传统腹腔镜在肝细胞性肝癌切除术中的临床效果。方法 选取70例肝细胞性肝癌患者,按照随机抽签法将其分为荧光组(n=35)和传统组(n=35),荧光组采用ICG荧光腹腔镜,传统组采用传统腹腔镜,比较两组患者围术期指标(手术时间、切缘距离、失血量),比较两组患者手术前及手术后3 d肝功能[血清总蛋白(TP)、血清白蛋白(ALB)、谷丙转氨酶(ALT)、碱性磷酸酶(ALP)]变化,炎症因子[白细胞(WBC)、降钙素原(PCT)、C-反应蛋白(CRP)]变化,随访6个月,观察两组患者无瘤生存期差异。结果 荧光组患者手术时间、术中失血量均优于传统组,荧光组切缘距离大于传统组,差异均有统计学意义(P<0.05),手术后3 d,两组患者TP、ALB、WBC、PCT和CRP较手术前均有所上升,且荧光组TP、ALB上升程度明显大于传统组,荧光组WBC、PCT和CRP明显低于传统组(P<0.05),两组患者ALT、ALP较手术前均有所下降,且荧光组下降程度明显大于传统组(P<0.05),术后6个月,两组患者无瘤生存期无显著差异(P>0.05)。结论 ICG荧光腹腔镜可有效促进肝细胞性肝癌患者肝功能的恢复,且对患者机体创伤较小,有利于患者术后恢复,可在临床上推广使用。
Objective To compare the clinical effects of indocyanine green(ICG) fluorescent laparoscopy and traditional laparoscopy in the resection of hepatocellular carcinoma.Methods 70 patients with hepatocellular carcinoma were selected and divided into fluorescent group(n=35) and traditional group(n=35) according to the random drawing method.ICG fluorescent laparoscopy was used in fluorescent group, and traditional laparoscopy was applied in traditional group.The perioperative indicators(surgical time, incision margin distance, blood loss) and liver function [serum total protein(TP),serum albumin(ALB),alanine aminotransferase(ALT),alkaline phosphatase(ALP)] and inflammatory factors [white blood cell(WBC),procalcitonin(PCT),C-reactive protein(CRP)] before surgery and at 3 days after surgery were compared between the 2 groups of patients.At 6 months of follow-up, the difference in tumor-free survival time in the 2 groups was observed.Results The surgical time and intraoperative blood loss of patients in fluorescent group were better than those in traditional group, and the distance of incision margin was longer than that in traditional group(P<0.05).At 3 days after surgery, TP, ALB,WBC,PCT and CRP in both groups were increased compared with those before surgery, and the increases of TP and ALB in fluorescent group were significantly greater than those in traditional group, and WBC,PCT and CRP were significantly lower than those in traditional group(P<0.05).ALT and ALP in the 2 groups were decreased compared to before surgery, and the decreases were significantly greater in fluorescent group(P<0.05),and there was no significant difference in tumor-free survival time between the 2 groups at 6 months after surgery(P>0.05).Conclusion ICG fluorescent laparoscopy can effectively promote the recovery of liver function in patients with hepatocellular carcinoma, and it has small trauma to the body and is beneficial to the postoperative recovery of patients.
作者
王沙沙
李靖
付雯
WANG Shasha;LI Jing;FU Wen(Henan People's Hospital,Zhengzhou,450000)
出处
《实用癌症杂志》
2023年第3期443-446,共4页
The Practical Journal of Cancer
关键词
吲哚菁绿荧光腹腔镜
传统腹腔镜
肝细胞性肝癌
Indocyanine green fluorescent laparoscopy
Traditional laparoscopy
Hepatocellular carcinoma
