摘要
目的 探讨血清二磷酸腺苷(ADP)、血栓弹力图中的最大振幅(MA)与非大血管闭塞急性缺血性脑卒中患者预后的相关性。方法 选取2019年1月至2022年5月在太和县人民医院神经内科进行就诊的缺血性脑卒中患者100例作为研究对象。100例患者以随机数字法分为观察组和对照组各50例,对照组50例接受阿司匹林治疗,观察组50例接受替罗非班治疗。依据两组预后情况(mRS评分)分为预后良好组和预后不良组,分析血清ADP、MA与非大血管闭塞急性缺血性脑卒中患者预后的关系。结果治疗3个月后,观察组血清ADP、MA均高于对照组,差异有统计学意义(t=2.830、7.844,P<0.05);预后良好组血清ADP、MA高于预后不良组,差异有统计学意义(t=3.313、2.287,P<0.05),MRS评分低于预后不良组,差异有统计学意义(t=19.685,P<0.05);Pearson相关性分析显示,血清ADP与mRS评分呈负相关(r=-0.272,P=0.006),与MA呈负相关(r=-0.203,P=0.043);Logistic回归分析显示,血清ADP、MA降低,MRS评分升高是非大血管闭塞急性缺血性脑卒中预后不良的独立影响因素(P<0.05);ROC曲线图显示,血清ADP的预测价值最高,AUC为0.725,敏感度为73.9%,特异度为64.5%。结论 非大血管闭塞急性缺血性脑卒中应用替罗非班治疗的效果显著,血清ADP、MA是非大血管闭塞急性缺血性脑卒中患者预后不良的独立微信因素,其中MA对非大血管闭塞急性缺血性脑卒中预后不良具有较高预测价值。
Objective To investigate the correlation between serum ADP and MA and the prognosis of patients with acute ischemic stroke without large vessel occlusion. Methods From January 2019 to May 2022,100 patients with ischemic stroke who were treated in the Department of Neurology,Taihe County People’s Hospital were selected as the research objects.100 patients were randomly divided into observation group and control group,50 cases in each group,50 cases in control group received aspirin treatment,and 50 cases in observation group received tirofiban treatment. According to the prognosis(mRS score),the two groups were divided into a good prognosis group and a poor prognosis group. The relationship between serum ADP and MA and the prognosis of patients with acute ischemic stroke without large vessel occlusion was analyzed.Results After 3 months of treatment,serum ADP and MA in the observation group were higher than those in the control group(t=2.830、7.844,P<0.05);The serum ADP and MA in the good prognosis group were higher than those in the poor prognosis group(t=3.313、2.287,P<0.05),and the MRS score was lower than that in the poor prognosis group(t=19.685,P<0.05);Pearson correlation analysis showed that serum ADP was negatively correlated with mRS score(r=-0.272,P=0.006),and negatively correlated with MA(r=-0.203,P=0.043);Logistic regression analysis showed that the decrease of serum ADP and MA and the increase of MRS score were independent influencing factors of poor prognosis of acute ischemic stroke without large vessel occlusion(P<0.05). The ROC curve showed that serum ADP had the highest predictive value,with an AUC of0.725,a sensitivity of 73.9%,and a specificity of 64.5%. Conclusion The effect of tirofiban in the treatment of acute ischemic stroke with non-large vessel occlusion is significant,and serum ADP and MA are related to the prognosis. Among them,MA has a high predictive value for the poor prognosis of acute ischemic stroke with non-large vessel occlusion.
作者
耿万杰
杨庆
谢红梅
张丹丹
GENG Wanjie;YANG Qing;XIE Hongmei;ZHANG Dandan(Department of Neurology,Taihe County People's Hospital,Taihe,Anhui,China,236600)
出处
《分子诊断与治疗杂志》
2023年第1期39-42,47,共5页
Journal of Molecular Diagnostics and Therapy
基金
阜阳市科技局项目(FK202081080)。
作者简介
通信作者:耿万杰,E⁃mail:gwj13705671927@163.com。
