摘要
目的:观察活血祛瘀方联合常规西药治疗急性上消化道出血的临床疗效。方法:选取80例急性上消化道出血患者为研究对象,采用随机数字表法分为对照组和观察组各40例。对照组给予常规西药治疗,观察组在对照组基础上给予活血化瘀方治疗。评价2组临床疗效,统计2组临床症状体征情况及不良反应发生率,比较2组治疗前后中医证候积分、凝血指标、胃黏膜指标及血流动力学指标变化情况。结果:观察组总有效率为95.00%,高于对照组80.00%(P<0.05)。观察组完全止血时间、腹痛消失时间短于对照组(P<0.05),胃管引流量、输血量少于对照组(P<0.05)。2组治疗后中医证候积分、纤维蛋白原水平、门静脉内径、门静脉血流速度、门静脉血流量低于治疗前,且观察组低于对照组(P<0.05);2组治疗后凝血酶原时间及凝血酶时间短于治疗前,且观察组短于对照组(P<0.05)。治疗后,2组空腹胃酸pH值高于治疗前,且观察组高于对照组(P<0.05);2组治疗后胃泌素、胃动素水平低于治疗前,且观察组低于对照组(P<0.05)。2组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论:活血祛瘀方联合常规西药治疗急性上消化道出血能促进凝血功能恢复,改善血流动力学,且能缩短临床症状消失时间,临床疗效显著。
Objective: To observe the clinical effect of Huoxue Quyu Recipe combined with routine western medicine for acute upper gastrointestinal bleeding. Methods:A total of 80 cases of patients with acute upper gastrointestinal bleeding were selected as the study subjects, and divided into the control group and the observation group according to the random number table method, with 40 cases in each group. The control group was treated with routine western medicine, and the observation group was treated with Huoxue Quyu Recipe based on the treatment of the control group. The clinical effects in the two groups were evaluated. The clinical symptoms and signs and the incidence of adverse reactions in the two groups were counted. Before and after treatment,the changes in traditional Chinese medicine(TCM)syndrome scores,coagulation indexes,gastric mucosal indexes,hemodynamic indexes were compared between the two groups. Results:The total effective rate was 95.00% in the observation group,higher than that of 80.00% in the control group(P<0.05). The complete hemostasis time and the disappearance time of abdominal pain in the observation group were earlier than those in the control group(P<0.05),and the drainage volume of gastric tube and the blood transfusion were less(P<0.05). After treatment,TCM syndrome scores,fibrinogen levels,and internal diameter,blood flow velocity and blood flow of portal vein in the two groups were lower than those before treatment,and the indexes in the observation group were lower than those in the control group(P<0.05);the prothrombin time and thrombin time in the two groups were shorter than those before treatment,and the time in the observation group was shorter than that in the control group(P<0.05). After treatment,the p H values of fasting acid in the two groups were higher than those before treatment, and the value in the observation group was higher than that in the control group(P<0.05);the levels of gastrin and motilin in the two groups were lower than those before treatment,and the levels in the observation group were lower than those in the control group(P<0.05).There was no significant difference being found in the comparison of the total incidence of adverse reactions between the two groups(P>0.05). Conclusion: Huoxue Quyu Recipe combined with routine western medicine has a significant clinical effect in treating acute upper gastrointestinal bleeding,which can promote the recovery of coagulation function, improve hemodynamics, and shorten the disappearance time of clinical symptoms.
作者
潘小琴
肖辉
尹强龙
PAN Xiaoqin;XIAO Hui;YIN Qianglong
出处
《新中医》
CAS
2023年第3期78-81,共4页
New Chinese Medicine
关键词
急性上消化道出血
活血祛瘀方
奥曲肽
泮托拉唑
中医证候积分
凝血功能
血流动力学
Acute upper gastrointestinal bleeding
Huoxue Quyu Recipe
Octreotide
Pantoprazole
Traditional Chinese medicine syndrome scores
Coagulation function
Hemodynamics
作者简介
潘小琴(1988-),女,主治中医师,E-mail:panxiaoqin008@163.com。
