摘要
目的探討呼出氣一氧化氮(fractional exhaled nitric oxide,FeNO)檢測在支氣管哮喘鑒別診斷中的臨床應用價值。方法回顧性分析2019年1月~12月在本院呼吸内科門診及住院疑似哮喘患者,測定患者FeNO水平,探討FeNO在支氣管哮喘鑒別診斷中的敏感度及特異度。結果納入156例患者中,最終確診哮喘106例,非哮喘50例。確診哮喘組FeNO水平高於非哮喘組((73.17±56.70)ppb vs(32.45±20.03)ppb,t=4.97,(P<0.05))。應用ROC曲線分析,診斷臨界點設為34.5ppb時,約登指數最大,診斷哮喘的敏感度為76.4%,特異度為80%,陽性預測值89%,陰性預測值61.5%,FeNO ROC曲線下最大面積為0.788(95%CI:0.71,0.86)。結論在哮喘鑒別診斷時,當FeNO大於34.5ppb時,對哮喘的診斷價值較大。
Objective The purpose of this study is to investigate the value of fractional exhaled nitric oxide(FeNO)in the differential diagnosis of bronchial asthma.Methods Retrospectively analyze the inpatients/outpatients with suspected bronchial asthma in the department of respiratory medicine in Kiang Wu hospital of Macao China from January to December 2019.All cases were carried out FeNO measurement.Receiver operating characteristic curve(ROC)was used to explore the sensitivity and specificity of FeNO in the diagnosis of bronchial asthma.Results 106 patients were diagnosed with bronchial asthma and the other 50 patients were non-asthma.The level of FeNO in the asthma group(73.17±56.70)ppb was significantly higher than that of the non-asthma group((32.45±20.03)ppb,t=4.97,(P<0.05)).According to the ROC curve analysis,Youden's index is the largest when the diagnostic cut-off point was 34.5 ppb,with the sensitivity of 76.4%and the specificity of 80%when making a diagnosis of asthma.The positive predictive value was 89%.The negative predictive value was 61.5%.The area under the ROC curve was 0.788(95%CI:0.71,0.86).Conclusion In the differential diagnosis of asthma,FeNO>34.5ppb,is more favor the diagnosis of asthma.
作者
郭凱欣
梁婷芝
馮芷軒
張曉戰
KUOK Hoi Ian;LEONG Teng Chi;FUNG Chi Hin;ZHANG Xiao Zhan(Department of Rehabilitation,Kiang Wu Hospital,Macao,China;Department of Respiratory Medicine,Kiang Wu Hospital,Macao,China)
出处
《镜湖医学》
2021年第2期5-7,共3页
MEDICAL JOURNAL OF KIANG WU
关键词
支氣管哮喘
呼出氣一氧化氮
診斷
Bronchial asthma
Fractional exhaled nitric oxide(FeNO)
Diagnosis
作者简介
通訊作者:張曉戰,E-mail:zxiao801@gmail.com。
