摘要
视神经脊髓炎谱系疾病(NMOSD)是以视神经和脊髓受累为主要表现的中枢神经系统自身免疫性脱髓鞘疾病,以视神经炎、急性脊髓炎、极后区综合征等为主要临床特征。其中水通道蛋白4(AQP4)抗体阳性患者占多数,且较AQP4抗体阴性患者临床症状更重、复发更频繁、致残率更高,但其发病机制尚不明确。文中对AQP4-IgG阳性NMOSD发病机制的研究进展进行综述。
Neuromyelitis optica spectrum disorder(NMOSD)is an autoimmune demyelinating disease of the central nervous system characterized by the involvement of the optic nerve and spinal cord.The main clinical features are optic neuritis,acute myelitis,and area postrema syndrome.Aquaporin-4(AQP4)-IgG-positive patients accounted for the majority and compared with AQP4-IgG-negative patients,the clinical symptoms were more severe,the recurrence was more frequent,and the disability rate was higher.The pathogenesis of AQP4-IgG-positive NMOSD is still not clear.This article reviews the research progress of the pathogenesis of AQP4-IgG-positive NMOSD.
作者
游云凡
秦川
田代实
周罗绮
You Yunfan;Qin Chuan;Tian Daishi;Zhou Luoqi(Department of Neurology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China)
出处
《中华神经科杂志》
CAS
CSCD
北大核心
2023年第2期227-232,共6页
Chinese Journal of Neurology
基金
国家自然科学基金面上项目(81873743)。
关键词
视神经脊髓炎
水通道蛋白4抗体
自身免疫
炎症
Neuromyelitis optica
Anti-aquaporin 4 autoantibody
Autoimmunity
Inflammation
作者简介
通信作者:周罗绮,Email:296765433@qq.com。
