摘要
目的:探讨飞秒激光辅助白内障手术对房水炎性因子、角膜知觉、眼高阶像差的影响。方法:选择2018年6月至2020年2月寿光市人民医院诊治的48例(56眼)白内障患者为研究对象,按随机数字表法分为观察组(飞秒激光辅助白内障超声乳化术,24例27眼)、对照组(同轴微切口白内障超声乳化术,24例29眼)。比较两组术前、术后房水前列腺素E2(PGE2)、白细胞介素(IL)-6、IL-1β水平;比较两组术前、术后7 d、术后1个月、术后3个月上方角膜和中央角膜知觉阈值;比较两组术前和术后4 mm瞳孔直径下全眼、角膜高阶像差。结果:观察组术后房水PGE2、IL-6、IL-1β水平低于对照组[(45.62±5.71)ng/L比(63.65±5.62)ng/L、(15.25±3.21)ng/L比(24.59±6.13)ng/L、(17.16±1.28)ng/L比(25.74±4.62)ng/L],差异有统计学意义(P<0.05)。观察组术后7 d上方及中央角膜知觉阈值高于对照组(4.55±0.50比4.20±0.33、5.68±0.49比5.52±0.45),差异有统计学意义(P<0.05)。两组术后全眼高阶像差各指标均降低(P<0.05);角膜高阶像差各指标无明显变化;两组术前、术后全眼及角膜高阶像差各指标比较差异均无统计学意义(P>0.05)。结论:飞秒激光辅助白内障手术能缓解炎性反应,减少全眼高阶像差,但不影响角膜,能改善角膜知觉。
Objective To investigate the effects of femtosecond laser assistcataract extraction on the levels of inflammatory factors in aqueous humor,corneal perception and high order aberration.Methods Forty-eight patients(56 eyes)undergoing cataract surgery in the Shouguang People′s Hospital from June 2018 to February 2020 were enrolled in this study,and they were divided into observation group(24 patients and 27 eyes,femtosecond laser cataract phacoemulsification)and control group(24 patients and 29 eyes,coaxial microincision phacoemulsification)by random number table method.The levels of prostglndin E2(PGE2),interleukin(IL)-6 and IL-1βin aqueous humor were detected before and after operation.Upper corneal and central corneal perception thresholds were recorded before surgery,7 d after surgery,1 month after surgery and 3 months after surgery.High order aberrations of the whole eye and cornea at 4mm pupil diameter before and after operation were recorded.Results After operation,the levels of PGE2,IL-6 and IL-1βin aqueous humor in the observation group were lower than those in the control group:(45.62±5.71)ng/L vs.(63.65±5.62)ng/L,(15.25±3.21)ng/L vs.(24.59±6.13)ng/L,(17.16±1.28)ng/L vs.(25.74±4.62)ng/L,the differences were statistically significant(P<0.05).The upper and central corneal perception threshold of observation group after operation for 7 d were higher than those in the control group:4.55±0.50 vs.4.20±0.33,5.68±0.49 vs.5.52±0.45,the differences were statistically significant(P<0.05).The indexes of high order aberration of the whole eye decreased in the two groups(P<0.05),while the indexes of cornea did not change significantly.The indexes of high order aberration of the whole eye and cornea between before and after surgery between the two groups had no significant differences(P>0.05).Conclusions Femtosecond laser assist cataractextraction can relieve inflammation,reduce the whole eye high order aberration,but not affect the cornea,and can improve corneal perception.
作者
吕召圆
董宁宁
栾红岩
姜涛
Lyu Zhaoyuan;Dong Ningning;Luan Hongyan;Jiang Tao(Department of Ophthalmology,Affiliated Hospital of Qingdao University,Qingdao 266003,China;Department of Ophthalmology,Shouguang People′s Hospital,Shouguang 262700,China)
出处
《中国医师进修杂志》
2023年第2期184-188,共5页
Chinese Journal of Postgraduates of Medicine
关键词
角膜外科手术
激光
白内障摘除术
房水
急性期反应
角膜知觉
高阶像差
Corneal surgery,laser
Cataract extraction
Aqueous humor
Acute phase reaction
Corneal perception
High order aberration
作者简介
通信作者:姜涛,Email:lanlandetian20000@163.com。
