摘要
肠-脑轴是一个双向的信息交流通路,肠道微生物群作为肠-脑轴的关键调节因子之一,不仅参与维持肠道稳态和调节肠道功能,还可以通过肠神经系统与大脑直接交流并相互传递信息。目前已有研究证实肠道微生物群的失调可能与神经退行性疾病、精神心理及代谢性疾病之间存在联系,但其背后的作用机制仍未阐明清楚。本文围绕磁共振成像技术在肠道微生物群失调与神经退行性疾病、精神心理及代谢性疾病的作用及研究进展,综述了肠道菌群与脑结构及功能的关联性,旨在探究肠道微生物在疾病中的作用机制以及为临床治疗提供理论支持。
The gut-brain axis is a bidirectional information communication pathway.As one of the key regulators of the gut-brain axis,the gut microbiota is not only involved in maintaining intestinal homeostasis and regulating intestinal function,but also can directly communicate and transmit information with the brain through the complex enteric nervous system.At present,studies have confirmed that the dysbiosis of intestinal microbiota may be related to neurodegenerative diseases,mental and metabolic diseases,but the mechanism behind it has not been clearly elucidated.Focusing on the role and research progress of magnetic resonance imaging technology in dysbiosis of intestinal microbiota and neurodegenerative disorders,psychosocial and metabolic diseases,this paper summarizes the correlation between intestinal microflora and brain structure and function,aiming to explore the action mechanism of intestinal microbes in diseases and provide theoretical support in clinical treatment.
作者
刘婉婷
张小玲
LIU Wanting;ZHANG Xiaoling(Graduate School of Xi'an Medical University,Xi'an 710068,China;MRI Room of Shaanxi Provincial People's Hospital,Xi'an 710068,China)
出处
《磁共振成像》
CAS
CSCD
北大核心
2023年第2期158-162,共5页
Chinese Journal of Magnetic Resonance Imaging
基金
国家自然科学基金(编号:82170820)
陕西省重点研发计划(编号:2018ZDXM-SF-038)。
关键词
肠道微生物群
肠-脑轴
磁共振成像
功能磁共振成像
多模态磁共振成像
gut microbial communities
gut-brain axis
magnetic resonance imaging
functional magnetic resonance imaging
multimodal magnetic resonance imaging
作者简介
通信作者:张小玲,E-mail:zxl.822@163.com。
