摘要
幽门螺杆菌(Hp)是一种革兰氏阴性菌,主要定植于胃和十二指肠,可引起胃炎、消化性溃疡和胃癌等疾病。抗生素是目前根除Hp的主要治疗药物,但随着抗生素的广泛应用,Hp的耐药性也逐年上升。本研究就Hp常用抗生素的耐药基因突变位点、新型检测方法和治疗药物进行综述,为根除Hp、选择敏感抗生素及制订个体化疗法提供参考。
Helicobacter pylori(Hp)is a Gram-negative bacterium that mainly colonizes the stomach and duodenum,which can cause gastritis,peptic ulcer and gastric cancer.Antibiotics are the main therapeutic drugs for eradicating Hp at present.However,but with the widely application of antibiotics,the drug resistance of Hp is also increasing year by year.This paper reviewed the mutation sites of resistance genes in the commonly used antibiotics for Hp,the new detection methods and therapeutic drugs,in order to provide reference for eradicating Hp,selecting sensitive antibiotics and formulating individualized therapy.
作者
邵慧娟
李初谊
于晓辉
张久聪
SHAO Huijuan;LI Chuyi;YU Xiaohui;ZHANG Jiucong(Gansu University of Traditional Chinese Medicine,Lanzhou,Gansu,730000;Department of Gastroenterology,the 940th Hospital of Joint Logistic Support Force of the Chinese People′s Liberation Army,Lanzhou,Gansu,730050)
出处
《实用临床医药杂志》
CAS
2023年第2期139-144,共6页
Journal of Clinical Medicine in Practice
基金
甘肃省自然科学基金面上项目(21JR7RA002)
甘肃省自然科学基金青年项目(22JR5RA1012)
甘肃省非感染性肝病临床医学研究中心(21JR7RA017)
中央高校优秀青年团队培育项目(31920220065)。
关键词
幽门螺杆菌
耐药性
基因突变
抗生素
疗法
Helicobacter pylori
drug resistance
gene mutation
antibiotics
therapy
作者简介
通信作者:张久聪,E-mail:zhangjiucong@163.com。
