孟鲁司特联合布地奈德辅助雾化吸入对小儿哮喘合并呼吸道病毒感染肺功能及血清免疫指标的影响被引量：2

Effect of assisted aerosol inhalation with Montelukast combined with Budesonide on pulmonary function and serum immune factors in children with asthma complicated with respiratory virus infection

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摘要目的探究在小儿哮喘伴呼吸道病毒感染的患儿中应用孟鲁司特联合布地奈德治疗对血清免疫指标和肺功能的影响。方法选取2019年3月至2021年3月东莞市虎门医院收治的96例小儿哮喘伴呼吸道病毒感染患儿为研究对象,按随机数字表法分为对照组和研究组,每组48例。对照组予以布地奈德雾化治疗,研究组予以孟鲁司特联合布地奈德雾化治疗。比较两组治疗前后的肺功能、血清免疫指标的变化。结果治疗后两组呼气峰流速、用力肺活量、第1秒用力呼气容积水平均高于治疗前,且研究组水平均高于对照组;治疗后IgG、IgA、IgM水平均高于治疗前,且研究组水平均高于对照组。差异均有统计学意义(P<0.05)。结论采用孟鲁司特联合布地奈德治疗小儿哮喘伴随呼吸道病毒感染,可改善肺部功能和血清免疫指标水平。 Objective To explore the effect of Montelukast combined with Budesonide on serum immune factors and lung function of children with asthma with respiratory virus infection.Methods A total of 96 children with asthma with respiratory virus infection admitted to Dongguan Humen Hospital from March 2019 to March 2021 were selected as study objects.They were divided into control group and study group according to random number table method,with 48 cases in each group.The control group was treated with Budesonide atomizing inhalation,while the study group was treated with atomizing inhalation with Montelukast combined with Budesonide.The changes of lung function and level of serum immune factors before and after treatment were compared between the two groups.Results After treatment,the peak expiratory flow rate,forced vital capacity and forced expiratory volume in one second of the two groups were higher than those before treatment,and the levels of the study group were higher than those of the control group.The levels of IgG,IgA and IgM after treatment were higher than those before treatment,and the levels of the study group were higher than those of the control group.The differences were statistically significant(P<0.05).Conclusion The application of Montelukast combined with Budesonide in the treatment of children asthma with respiratory virus infection can improve lung function and level of serum immune factors.

作者吴建潮 WU Jianchao(Department of Pharmacy,Dongguan Humen Hospital,Guangdong Province,Dongguan523900,China)

机构地区广东省东莞市虎门医院药剂科

出处《妇儿健康导刊》 2023年第4期106-108,共3页 JOURNAL OF WOMEN AND CHILDREN'S HEALTH GUIDE

关键词孟鲁司特布地奈德雾化吸入小儿哮喘呼吸道病毒感染 Montelukast Budesonide Atomizing inhalation Asthma in children Respiratory virus infection

分类号 R725.6 [医药卫生—儿科]