摘要
目的 探讨乳腺癌患者手术后不同预后结局与患者基线血脂水平的关系。方法 本研究采取病例对照研究方法,选取某医院2013年12月—2017年5月采取手术治疗的乳腺癌患者进行研究,其中术后5年内出现转移复发的患者32例作为复发转移组、同期手术后未出现复发转移的患者70例作为对照组,对比二组患者的基线资料、基线血脂水平、病理学特征水平,采用Logistic回归模型分析基线血脂水平对乳腺癌患者预后结局的影响作用大小。结果 复发转移组的病理学分型、HER-2表达、肿瘤组织学分级、Ki-67表达、ER表达、PR表达与对照组比较,二组患者差异无统计学意义(P>0.05);复发转移组患者的TNM分期中>Ⅱ期患者占比、淋巴结转移阳性率大于对照组,差异具有统计学意义(P<0.05);复发转移组的血清TG、TC测定值均高于对照组,复发转移组的ApoA1低于对照组,差异均具有统计学意义(P<0.05);复发转移组和对照组的HDL-C、LDL-C、ApoB、APOE测定值比较,差异无统计学意义(P>0.05);Logistic回归模型结果显示:TNM分期>Ⅱ期、淋巴结转移阳性、TG增高、ApoA1降低是患者手术后5年内出现复发转移的独立危险因素(P<0.05)。结论 乳腺癌手术后复发转移的影响因素很多,患者基础血脂水平升高是其复发转移的独立危险因素之一,因此合理调节乳腺癌患者的血脂水平对降低复发风险具有一定的价值。
Objective To investigate the relationship between different prognostic outcomes and baseline blood lipid levels in patients with breast cancer after surgery.Methods The case-control study method was adopted in this study,and the breast cancer patients who received surgical treatment from December 2013 to May 2017 in our hospital were selected for research.Among them,thirty two patients with metastasis and recurrence within 5 years after surgery were selected as the recurrence and metastasis group.70 patients without recurrence and metastasis after surgery during the same period were used as the control group.The baseline data,baseline blood lipid levels,and pathological characteristics of the two groups of patients were compared,and the effect of baseline blood lipid levels on the prognosis of breast cancer patients was analyzed by Logistic regression model.size.Results Compared with the control group,the pathological type,HER-2 expression,tumor histological grade,Ki-67 expression,ER expression and PR expression in the recurrence and metastasis group had no significant difference between the two groups(P>0.05).In the TNM staging of patients in the group,the proportion of patients with>Ⅱ stage and the positive rate of lymph node metastasis were higher than those in the control group,and the difference was statistically significant(P0.05);Logistic regression model results showed that TNM stage>Ⅱ,positive lymph node metastasis,increased TG,and decreased ApoA1 were independent risk factors for recurrence and metastasis within 5 years after surgery(P<0.05).Conclusion There are manyinfluencing factors for the recurrence and metastasis of breast cancer after surgery.The elevated blood lipid level of patients is one of the independent risk factors for recurrence and metastasis.Therefore,reasonable adjustment of blood lipid levels in breast cancer patients has certain value in reducing the risk of recurrence.
作者
杜虎臣
何军
陈令
DU Huchen;HE Jun;CHEN Ling(903 hospital,Mianyang,621700,China)
出处
《中国煤炭工业医学杂志》
2022年第6期634-638,共5页
Chinese Journal of Coal Industry Medicine
基金
四川省卫生和计划生育委员会科研课题(编号:18PJ307)。
关键词
乳腺癌
预后
血脂
复发
转移
Breast cancer
Prognosis
Blood lipids
Recurrence
Metastasis
作者简介
通讯作者:何军。
