摘要
近年来,细胞疗法在难愈合创面修复领域的应用显示出广阔前景,其中间充质干细胞是最受关注和研究最为广泛的细胞类型。尽管临床转化研究已取得快速发展,但细胞疗法效果并不稳定,多数临床试验尚未取得预想结果。深入研究表明,异质性是制约细胞疗法深入开展和亟待研究的重要问题。该文基于间充质干细胞的研究进展,探讨难愈合创面细胞治疗策略的现状和挑战。
In recent years,the application of cell-based therapy in the field of refractory wound repair has shown broad prospects,among which the mesenchymal stem cell is the most concerned and widely studied cell type.Despite the rapid development of clinical translational research,the therapeutic effect of cell-based therapy is not consistent,and most clinical trials have not achieved the desired results.Further studies have found that heterogeneity is an important issue that restricts the further development of cell-based therapy and urgently needs to be studied.Based on the research progress of mesenchymal stem cells,in the review,we discuss the current status and challenges of cell-based therapy strategies for refractory wounds.
作者
史春梦
Shi Chunmeng(Institute of Rocket Force Medicine,State Key Laboratory of Trauma,Burns and Combined Injury,Army Medical University,Chongqing 400038,China)
出处
《中华烧伤与创面修复杂志》
CAS
CSCD
北大核心
2022年第11期999-1003,共5页
Chinese Journal of Burns And Wounds
基金
国家自然科学基金重点项目(82030056)。
关键词
间充质干细胞
细胞和组织疗法
转化医学研究
难愈合创面
创面修复
异质性
Mesenchymal stem cells
Cell-and tissue-based therapy
Translational medical research
Refractory wounds
Wound repair
Heterogeneity
作者简介
史春梦,Email:shicm@sina.com。
