摘要
Dear Editor,Targeting senescence therapy is a promising anticancer strategy by arresting the cell-cycle and inducing cellular senescence.However,senescent cells can promote malignancy and drug resistance.1,2 Thus,with the induction of senescence emerged as a viable therapeutic concept,it is important to consider how to eliminate those senescent cancer cells.
基金
supported by the National Natural Science Foundation of China(Grant Nos.81820108022,22177076,22037002)
Innovation Program of Shanghai Municipal Education Commission(2019-01-07-00-10-E00056,2021-01-07-00-02-E00104)
The Scientific and Technological Innovation Action Plan of Science and Technology Commission of Shanghai(20JC1411300)
Shanghai Frontiers Science Center of Disease and Syndrome Biology of Inflammatory Cancer Transformation(2021KJ03-12)
National Thirteenth Five-Year Science and Technology Major Special Project for New Drug and Development(2017ZX09304001)
the Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell Metabolism(2021 Sci&Tech 03-28)
the Innovative Research Team of High-level Local Universities in Shanghai and the Chinese Special Fund for State Key Laboratory of Bioreactor Engineering(2060204).
作者简介
Shuaishuai Ni,contributed equally;Qian Liu,contributed equally;Xin Chen,contributed equally;Lele Ding,contributed equally;Correspondence:Jian Li(jianli@ecust.edu.cn)Correspondence:Lijun Jia(ljjia@shutcm.edu.cn)。
