摘要
肠菌作为肠道微生态最主要的构成成分直接或间接地调控宿主的表观遗传修饰、各种代谢和黏膜乃至全身免疫功能,对结直肠癌的生物学行为产生较大的影响。尽管某些肠菌参与结直肠癌进程的详细机制尚未明了,但其作为结直肠癌早期预警、预后预测的可能标志物及治疗和预防的潜在靶点,为结直肠癌防治带来新希望。
As the main composition of the gut microbiota,intestinal microbiota directly or indirectly regulate epigenetic modifications,a variety of metabolisms,mucosal and even systemic immune functions of the host,and exert a great influence on the biological behavior of colorectal cancer.Although the detailed mechanism of some enterobacteria involved in the progression of colorectal cancer remains unclear,they are possible markers for early warning and prognostic prediction of colorectal cancer,as well as potential targets for treatment and prevention,which provides us with new hope for the prevention and treatment of colorectal cancer.
作者
房静远
邹天慧
Fang Jingyuan;Zou Tianhui(Department of Gastroenterology,Renji Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200001,China)
出处
《中华医学杂志》
CAS
CSCD
北大核心
2022年第46期3654-3657,共4页
National Medical Journal of China
关键词
结直肠肿瘤
腺瘤
肠道菌群
早期预警
防治
Colorectal neoplasms
Adenoma
Intestinal flora
Early warning
Prevention and treatment
作者简介
通信作者:房静远,Email:fangjingyuan_new@163.com。
