摘要
目的:观察他克莫司联合小剂量糖皮质激素治疗免疫球蛋白A肾病(IgAN)患者的效果。方法:选取2018年9月至2020年5月该院收治的124例IgAN患者进行前瞻性研究,按照随机数字表法分为对照组和观察组各62例。对照组给予小剂量糖皮质激素治疗,观察组给予他克莫司联合小剂量糖皮质激素治疗,比较两组疗效、肾功能指标[胱抑素C(CysC)、血尿氮素(BUN)、24 h尿蛋白(24hUP)、血肌酐(Scr)]水平、血清细胞因子指标[血管内皮生长因子(VEGF)、白细胞介素-17(IL-17)、IL-23]水平和不良反应发生率。结果:观察组治疗总有效率为91.94%,高于对照组的74.19%,差异有统计学意义(P<0.05);治疗后,两组CysC、BUN、24hUP、Scr、VEGF、IL-23、IL-17水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率为11.29%,对照组不良反应发生率为14.52%,两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:他克莫司联合小剂量糖皮质激素治疗IgAN患者可提高治疗总有效率,降低肾功能指标和血清细胞因子指标水平,优于单纯小剂量糖皮质激素治疗效果。
Objective:To observe effects of Tacrolimus combined with low-dose glucocorticoids in treatment of immunoglobulin A(IgA)nephropathy(IgAN).Methods:A prospective study was conducted on 124 IgAN patients admitted to the hospital from September 2018 to May 2020.They were divided into control group and observation group according to the random number table method,62 cases in each.The control group was treated with low-dose glucocorticoids,while the observation group was treated with Tacrolimus combined with low-dose glucocorticoids.The efficacy,the renal function index levels[cystatin C(CysC),blood urine nitrogen(BUN),24 h urine protein(24hUP),serum creatinine(Scr)],the serum cytokine index levels[vascular endothelial growth factor(VEGF),interleukin-17(IL-17),IL-23],and incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the observation group was 91.94%,which was higher than 74.19%in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of CysC,BUN,24hUP,Scr,VEGF,IL-23 and IL-17 in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Further,the incidence of adverse reactions was 11.29%in the observation group and 14.52%in the control group,and the difference was not statistically significant(P>0.05).Conclusions:Tacrolimus combined with low-dose glucocorticoids in the treatment of the IgAN patients can improve the total effective rate of treatment,reduce the levels of renal function indexes and the serum cytokine indexes.Moreover,it is superior to single low-dose glucocorticoids treatment.
作者
邢梅军
XING Meijun(Urology Department of Henan Yumei Nephropathy Hospital,Hebi 456750 Henan,China)
出处
《中国民康医学》
2022年第22期47-49,53,共4页
Medical Journal of Chinese People’s Health
作者简介
邢梅军(1978.12-),女,汉族,河南鹤壁人,本科,主治医师,研究方向为肾病方向。
