摘要
纳米粒是药物递送系统研究的热点之一,但仍存在体内循环时间短,易被网状内皮系统识别和清除等缺点,限制了其临床应用。近年来,天然细胞膜成分和纳米技术的结合为解决这些问题提供了新的方案。一种由纳米粒核和细胞膜壳组成的新型仿生系统极大地改善了纳米粒的性能。用细胞膜修饰的纳米粒具有独特的功能,如延长血液循环时间,提高主动靶向和增强细胞内化等功能。本文综述了细胞膜修饰纳米粒药物递送系统的最新进展及其在癌症治疗方面的应用前景。
Nanoparticles that are research hotspots in drug delivery systems,still have some disadvantages such as short circulation time in vivo,ease of recognition and clearance by reticuloendothelial system,which limit clinical applications.In recent years,the combinations of natural cell membrane components and nanotechnology have provided new solutions to these problems.A novel bionic system composed of nanoparticle core and cell membrane shell greatly can improve the performance of nanoparticles.Nanoparticles coated by cell membranes are endowed with unique functions such as prolonged blood circulation,active targeting capability and enhanced internalization.This review focus on the newest development of cell membranemodified nanoparticles drug delivery systems and introduce their application prospects in cancer therapy.
作者
陈星妍
崔韶晖
杜桑
张树彪
CHEN Xingyan;CUI Shaohui;DU Sang;ZHANG Shubiao(Key Laboratory of Biotechnology and Bioresources Utilization,Ministry of Education,Dalian Minzu University,Dalian 116600,China)
出处
《中国现代应用药学》
CAS
CSCD
北大核心
2022年第22期3024-3029,共6页
Chinese Journal of Modern Applied Pharmacy
基金
国家自然科学基金项目(21776044)。
关键词
细胞膜
纳米粒
仿生纳米粒
药物递送系统
癌症治疗
cell membrane
nanoparticles
biomimetic nanoparticles
drug delivery system
tumor therapy
作者简介
陈星妍,女,硕士生,E-mail:2524475075@qq.com;通信作者:崔韶晖,女,博士,副教授,E-mail:csh@dlnu.edu.cn;通信作者:张树彪,男,博士,教授,E-mail:zsb@dlnu.edu.cn。
