摘要
目的:评估痫愈胶囊治疗癫痫的经济性。方法:基于1篇已发表的随机对照试验,从卫生体系角度出发,构建痫愈胶囊联合丙戊酸镁缓释片治疗癫痫的决策树模型,以治疗前后癫痫发作次数减少率为效果指标,以药品成本和疾病治疗的年度门诊诊疗费用计算成本参数,评价痫愈胶囊联合丙戊酸镁缓释片相比单独使用丙戊酸镁缓释片在癫痫患者中的经济性,并采用敏感性分析对结果的稳健性进行验证。结果:成本-效果分析结果显示,患者用药治疗60 d后,痫愈胶囊联合丙戊酸镁缓释片治疗方案能够明显减少仅使用丙戊酸镁缓释片治疗期间的癫痫发作次数;痫愈胶囊联合丙戊酸镁缓释片治疗方案的治疗成本高于仅使用丙戊酸镁缓释片,效果产出也高于仅使用丙戊酸镁缓释片,增量成本-效果比为7051.79元,约为2020年我国人均可支配收入的0.22倍;敏感性分析结果表明,本研究结果相对稳健。结论:本研究中患者的意愿支付阈值为2020年我国人均可支配收入,在该假设下采用痫愈胶囊联合丙戊酸镁缓释片治疗比单独使用丙戊酸镁缓释片治疗更具有经济性。开展痫愈胶囊治疗癫痫的经济学评价,有利于合理配置医疗资源,便于医师和患者合理使用药物。
OBJECTIVE:To evaluate the economy of Xianyu capsules in the treatment of epilepsy.METHODS:Based on a published randomized controlled trial,the decision tree model of treating epilepsy with Xianyu capsules combined with Magnesium valproate sustained-release tablets was constructed from the perspective of health system.The reduction rate of epilepsy before and after treatment was taken as the effect index,and the cost parameters were calculated based on the drug cost and the annual outpatient treatment cost of disease treatment.The economy of Xianyu capsules combined with Magnesium valproate sustained-release tablets compared with magnesium valproate sustained-release tablets alone in the treatment of patients with epilepsy was evaluated.Sensitivity analysis was used to verify the robustness of the results.RESULTS:The cost-effectiveness analysis showed that after 60 d of treatment,the treatment regimen of Xianyu capsules combined with Magnesium valproate sustained-release tablets could significantly reduce the number of epilepsy.The treatment cost of Xianyu capsules combined with Magnesium valproate sustained-release tablets was higher than that of magnesium valproate sustained-release tablets alone,and the effective output was also higher than that of Magnesium valproate sustained-release tablets alone.The incremental cost-effectiveness ratio was 7051.79 yuan,about 0.22 times of the per capita disposable income of China in 2020.Sensitivity analysis showed that the results of this study were relatively stable.CONCLUSIONS:The willingness to pay threshold of the patients in this study is the per capita disposable income of China in 2020.Under this assumption,Xianyu capsules combined with Magnesium valproate sustained-release tablets is more economical than Magnesium valproate sustained-release tablets alone.Economic evaluation of Xianyu capsules in the treatment of epilepsy is conducive to rational allocation of medical resources and rational use of drugs by clinicians and patients.
作者
雷超
崔鑫
王志飞
谢雁鸣
LEI Chao;CUI Xin;WANG Zhifei;XIE Yanming(Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China)
出处
《中国医院用药评价与分析》
2022年第11期1365-1367,1374,共4页
Evaluation and Analysis of Drug-use in Hospitals of China
基金
国家重点研发计划项目(No.2018YFC1707410)
中国中医科学院科技创新工程重大攻关项目(No.CI2021A00702)。
关键词
痫愈胶囊
癫痫
药物经济学评价
决策树模型
丙戊酸镁缓释片
Xianyu capsules
Epilepsy
Pharmacoeconomic evaluation
Decision tree model
Magnesium valproate sustained-release tablets
作者简介
雷超,博士研究生。研究方向:中药上市再评价。E-mail:chaolei2021@163.com;通信作者:王志飞,研究员。研究方向:中药上市后评价。E-mail:wzhftcm@163.com;通信作者:谢雁鸣,首席研究员。研究方向:中药上市后评价。E-mail:ktzu2018@163.com。
