摘要
以乳酸锌为芯材,乳清蛋白和麦芽糊精为壁材,利用超声乳化辅助制备油包水(W/O)型微胶囊。考察壁材质量比、超声时间和超声功率对微胶囊包埋率、载药量及粒径的影响;以包埋率为评价指标,采用正交试验优化制备工艺;利用傅里叶红外光谱(FT-IR)、差式扫描量热分析(DSC)、热重分析(TG)、电镜和马尔文激光粒度仪对微胶囊进行表征。结果表明:最佳制备工艺条件为壁材质量比1∶1、超声时间20 min、超声功率700 W,在此条件下包埋率为79.12%±0.43%、载药量为27.82%±0.98%、粒径为(161.45±2.14)μm、水分含量为2.15%±0.17%、表面油为1.01%±0.13%、总油为33.75%±0.24%。表征结果显示微胶囊囊壁未破损,粒径分布均匀,具有良好的稳定性。
Taking zinc lactate as the core material,whey protein and maltodextrin as the wall material,ultrasonic emulsification was used to assist in the preparation of water-in-oil(W/O) microcapsules.The effects of wall material mass ratio,ultrasound time,and ultrasound power on the embedding rate,drug loading,and particle size of microcapsule were investigated.The preparation process was optimized by orthogonal experiment using embedding rate as an evaluation index.The microcapsule was characterized by Fourier transform infrared spectroscopy(FT-IR),differential scanning calorimetry(DSC),thermogravimetric analysis(TG),electron microscope,and Malvern laser particle size analyzer.The results showed that the optimum preparation conditions were 1 ∶1 wall material mass ratio,ultrasound time 20 min,and ultrasound power 700 W.Under these conditions,the embedding rate was 79.12 %±0.43 %,the drug loading was 27.82 %±0.98 %,the particle size was(161.45±2.14) μm,the moisture content was 2.15 %±0.17 %,surface oil was 1.01 %±0.13 %,and the total oil was 33.75 %±0.24 %.The characterization results showed that the microcapsule wall was undamaged,the particle size distribution was uniform,and it had good stability.
作者
袁传勋
王成成
金日生
YUAN Chuan-xun;WANG Cheng-cheng;JIN Ri-sheng(School of Food and Biological Engineering,Hefei University of Technology,Hefei 230601,Anhui,China;Engineering Research Center of Bio-process,Ministry of Education,Hefei University of Technology,Hefei 230601,Anhui,China)
出处
《粮食与油脂》
北大核心
2022年第11期93-98,118,共7页
Cereals & Oils
基金
安徽省科技重大专项(201903a06020024)
安徽省六安市产学研合作重大专项(JZ2020AHDS0258)。
关键词
乳酸锌
微胶囊
油包水
超声
乳化
zinc lactate
microcapsule
water in oil
ultrasound
emulsification
作者简介
袁传勋(1964-),男,博士,研究员,研究方向为天然活性物质研发、功能油脂;通信作者:金日生(1982-),男,博士,助理研究员,研究方向为农产品加工。
