摘要
糖尿病(diabetes mellitus,DM)是一组由遗传和环境因素共同参与的临床综合征,可导致以高血糖为特征的慢性代谢性疾病的发生。另外长期的代谢紊乱等可导致眼、肾、心血管等多脏器组织损害,影响病人的生活质量,甚至导致死亡。长链非编码RNA(Long non-coding RNAs,LncRNAs)是一类非编码蛋白的RNA分子,其数量庞大、种类繁多,转录本长度超过200个碱基。最初这些LncRNAs被认为是“转录噪音”,然而随着microRNA、siRNA等非编码RNA分子作用的逐步揭示,研究者们开始重新关注非编码RNA的生物学功能。近年来,LncRNAs因其对多种分子途径的影响而深受重视。另外有研究证实LncRNAs在糖尿病的病理进程中起着关键的调节作用。本综述旨在探讨LncRNAs与糖尿病及其并发症的关系,为其今后疾病的研究和治疗提供理论依据。
Diabetes mellitus(DM)is a group of clinical syndromes caused by the interaction of genetic and environmental factors,which can lead to the occurrence of chronic metabolic diseases characterized by hyperglycemia.Moreover,long-term metabolic disorders can lead to multiple organ tissue damage,such as eye,kidney and cardiovascular disease,affecting patients’quality of life and even death.Long non-coding RNAs(LncRNAs)are a class of RNA molecules that do not encode proteins featuring large number.The number of LncRNAs is huge,with transcripts over 200 nucleotides in length.LncRNAs were originally considered to be“transcriptional noise”.However,with the gradual revelation of the roles of ncRNA molecules,such as microRNAs and small interfering RNAs(siRNAs),researchers have begun to pay renewed attention to their biological functions.LncRNAs have attracted much attention in recent years owing to their influence on a variety of molecular pathways.In addition,studies have confirmed that LncRNAs play a key regulatory role in the pathological process of diabetes.This review briefly summarized and discussed the relationship between LncRNAs and diabetes and its complications,so as to provide theoretical basis for the research and treatment of diabetes mellitus.
作者
杨沁之(综述)
罗茂(审校)
YANG Qinzhi;LUO Mao(Department of Pharmacology,School of Pharmacy,Southwest Medical University,Luzhou 646000,China;Drug Discovery Research Center,Southwest Medical University,Luzhou 646000,China)
出处
《西南医科大学学报》
2022年第6期539-544,共6页
Journal of Southwest Medical University
基金
国家自然科学基金(81800434)
四川省科技厅项目(2019YJ0487)
泸州市科技局项目(2021-RCM-113)。
作者简介
第一作者:杨沁之,硕士研究生;通信作者:罗茂,博士,研究员,硕导,E-mail:luomao20050908@163.com。
