摘要
目的:分析四联疗法抗幽门螺杆菌(Hp)感染的临床疗效。方法:选取2020年7月-2021年7月房山区韩村河镇社区卫生服务中心收治的Hp感染患者50例,随机分为对照组和试验组,各25例。对照组患者使用三联疗法治疗,试验组患者使用四联疗法治疗。对比两组患者治疗后临床疗效、^(13)C-尿素水平、Hp根除率、药物不良反应情况。结果:试验组患者治疗后总有效率为96.00%,高于对照组的76.00%,差异有统计学意义(P<0.05)。试验组患者治疗后^(13)C-尿素水平低于对照组,Hp根除率高于对照组,差异有统计学意义(P<0.05)。试验组患者治疗后药物不良反应发生率为4.00%,低于对照组的24.00%,差异有统计学意义(P<0.05)。结论:Hp感染患者使用四联疗法治疗能够降低^(13)C-尿素水平,提高临床疗效及Hp根除率,药物不良反应小,值得推广应用。
Objective:To analyze the clinical therapy of quadruple therapy against Helicobacter pylori infection.Methods:Fifty patients with Helicobacter pylori infection treated in Hancunhe Town Community Health Service Center of Fangshan District from July 2020 to July 2021 were selected and randomly divided into control group and experimental group,with 25 cases in each group.The patients in the control group were treated with triple therapy,and the patients in the experimental group were treated with quadruple therapy.The clinical efficacy,level of ^(13)C-urea,Helicobacter pylori eradication rate and drug adverse reactions after treatment were compared between the two groups.Results:The total effective rate of patients in the experimental group after treatment was 96.00%,which was higher than 76.00%in the control group,and the difference between the two groups was statistically significant(P<0.05).The level of ^(13)C-urea in the experimental group after treatment was lower than that in the control group,and the Helicobacter pylori eradication rate was higher than that in the control group,and the difference between the two groups was statistically significant(P<0.05).The incidence of drug adverse reactions after treatment in the experimental group was 4.00%,which was lower than 24.00%in the control group,and the difference between the two groups was statistically significant(P<0.05).Conclusion:The use of quadruple therapy in patients with Helicobacter pylori infection can reduce the level of ^(13)C-urea,increase the clinical efficacy and Helicobacter pylori eradication rate,have mild drug adverse reactions.It deserves the promotion and application.
作者
耿淑凤
Geng Shu-feng(General Practice Department,Hancunhe Town Community Health Service Center of Fangshan District,Beijing 102423,China)
出处
《中国社区医师》
2022年第29期31-33,共3页
Chinese Community Doctors
