摘要
目的探讨乙型肝炎慢加急性肝衰竭患者血清白细胞介素-12(interleukin-12,IL-12)、血管内皮生长因子(vascular endothelial growth factor,VEGF)、可溶性生长刺激表达基因2(soluble growth-stimulating expression gene 2,sST2)、单核细胞趋化蛋白-1(monocyte chemotactic protein-1,MCP-1)水平变化及其与肝功能的相关性。方法选择2020年6月至2021年6月杭州市西溪医院收治的50例乙型肝炎病毒感染慢加急性肝衰竭(acute-on-chronic liver failure,HBV-ACLF)患者(HBV-ACLF组)、50例单纯慢性乙型肝炎(chronic hepatitis B,CHB)患者(CHB组)、50名健康人员(对照组)作为研究对象,比较3组患者的肝功能各项指标天门冬氨酸转氨酶(aspartate aminotransferase,AST)、丙氨酸转氨酶(alanine aminotransferase,ALT)、总胆红素(total bilirubin,TBiL)、白蛋白(albumin,ALB)及血清IL-12、VEGF、sST2、MCP-1的表达水平,并比较血清IL-12、VEGF、sST2、MCP-1水平和肝功能指标的相关性。结果HBV-ACLF组AST、ALT、TBiL、血清IL-12、VEGF、sST2、MCP-1水平均高于CHB组与对照组,ALB均低于CHB组与对照组,CHB组AST、ALT、TBiL、血清IL-12、VEGF、sST2、MCP-1水平均高于对照组,ALB均低于对照组,差异均有统计学意义(P<0.05);皮尔逊(Pearson)相关性分析显示,血清IL-12、VEGF、sST2、MCP-1和AST、ALT、TBiL均呈正相关,与ALB呈负相关(P<0.05)。结论血清IL-12、VEGF、sST2、MCP-1水平在HBV-ACLF患者中表达明显升高,与患者的肝功能具有相关性。
Objective To investigate the changes of serum interleukin-12(IL-12),vascular endothelial growth factor(VEGF),soluble growth stimulation expression gene 2(sST2),monocyte chemotactic protein-1(MCP-1)levels and their correlation with liver function in patients with chronic hepatitis B plus acute liver failure.Methods A total of 50 patients with chronic hepatitis B(CHB)virus infection with acute liver failure(HBV-ACLF group),50 patients with chronic hepatitis B(CHB group)and 50 healthy persons(control group)from June 2020 to June 2021 in Hangzhou Xixi Hospital were selected as the research objects.The expressions of liver function indexes aspartate aminotransferase(AST),alanine aminotransferase(ALT),total bilirubin(TBiL),albumin(ALB)and serum IL-12,VEGF,sST2 and MCP-1 levels in three groups were compared,the correlation between serum IL-12,VEGF,sST2,MCP-1 levels and liver function indexes was compared.Results The AST,ALT,TBiL,serum IL-12,VEGF,sST2 and MCP-1 levels in HBV-ACLF group were higher than the CHB group and control group,while ALB was lower than those in CHB group and control group,and the AST,ALT,TBiL,serum IL-12,VEGF,sST2 and MCP-1 levels in CHB group were higher than the control group,while ALB was lower than those in control group,with statistical significance(P<0.05).The Pearson correlation analysis showed that serum IL-12,VEGF,ST2,MCP-1 were positively correlated with AST,ALT and TBIL,and negatively correlated with ALB(P<0.05).Conclusion The serum IL-12,VEGF,sST2 and MCP-1 levels are significantly increased in patients with HBV-ACLF,and are correlated with the liver function.
作者
陈媛
荀运浩
谌翠容
孙振江
CHEN Yuan;XUN Yunhao;CHEN Cuirong;SUN Zhenjiang(Department of Hepatology,Hangzhou Xixi Hospital,Zhejiang,Hangzhou 310023,China)
出处
《中国现代医生》
2022年第30期44-47,共4页
China Modern Doctor
基金
浙江省中医药科技计划项目(2021ZB234)。
作者简介
通讯作者:陈媛,电子信箱:forever821103@126.com。
