摘要
目的探讨盐酸纳洛酮联合单唾液酸四己糖神经节苷脂钠治疗新生儿缺血缺氧性脑病的临床效果。方法选取2019年1月至2021年1月我院收治的102例新生儿缺血缺氧性脑病患儿作为研究对象,根据随机抽签分组法将其分为对照组和观察组,各51例。对照组行盐酸纳洛酮治疗,观察组在对照组基础上行单唾液酸四己糖神经节苷脂钠治疗。比较两组的治疗效果。结果观察组的治疗总有效率高于对照组,差异具有统计学意义(P<0.05)。观察组的肌张力恢复时间、意识恢复时间、吸吮恢复时间、住院时间短于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的智力发育指数(MDI)、精神运动发育指数(PDI)、精神运动发育商(DQ)评分高于对照组,差异具有统计学意义(P<0.05)。两组的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论盐酸纳洛酮联合单唾液酸四己糖神经节苷脂钠治疗新生儿缺血缺氧性脑病的效果显著,有利于提高患儿的发育状态,且安全性好,值得临床应用。
Objective To explore the clinical effect of naloxone hydrochloride combined with monosialotetrra-hexosylganglioside sodium in treatment of neonatal hypoxic ischemic encephalopathy.Methods A total of 102 children with neonatal hypoxic ischemic encephalopathy admitted in our hospital from January 2019 to January 2021 were selected as research objects.According to the random lottery grouping method,the children were divided into control group and observation group,with 51 cases in each group.The control group was treated with naloxone hydrochloride,and the observation group was treated with monosialotettrahexosylganglioside sodium on the basis of the control group.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).The muscle tension recovery time,consciousness recovery time,sucking recovery time and hospitalization time in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the scores of mental development index(MDI),psychomotor development index(PDI)and development quotient(DQ)in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Naloxone hydrochloride combined with monosialotettrahexosylganglioside sodium in the treatment of neonatal hypoxic ischemic encephalopathy has significant effect,it is beneficial to improving the development status of children,and has good safety.It is worthy of clinical application.
作者
万彩红
马明珠
WAN Caihong;MA Mingzhu(XD Group Hospital,Xi'an 710077,China)
出处
《临床医学研究与实践》
2022年第32期79-81,共3页
Clinical Research and Practice
作者简介
万彩红(1973-),女,副主任医师,学士。研究方向:新生儿脑损伤;通讯作者:马明珠,E-mail:846573512@qq.com.
