摘要
胃食管反流病(GERD)是一种涉及多因素的消化系统常见病。近年来,随着16S rRNA测序技术和宏基因组学研究的应用与发展,发现GERD食管菌群的改变引起广泛研究,其受到年龄、饮食、吸烟、药物、口腔、胃内微生物群等因素的影响。本文就正常食管和GERD患者的食管菌群特征、影响因素、潜在干预措施等的研究进展作一综述。
Gastroesophageal reflux disease(GERD)is a commonly seen digestive system disease involving multiple factors.In recent years,with the application and development of 16S rRNA sequencing technology and metagenomics research,changes of GERD esophageal flora had been extensively studied,and showed that the esophageal flora was affected by factors such as age,diet,smoking,drugs,oral cavity,and stomach microbiota.This article reviewed the advances in research on characteristics of normal esophageal flora and esophageal flora of GERD patients,the influencing factors and potential intervention measures.
作者
尹红
唐艳萍
YIN Hong;TANG Yanping(Tianjin University of Traditional Chinese Medicine,Tianjin301617;Department of GastroenterologyⅡ,Tianjin Nankai Hospital,Tianjin)
出处
《胃肠病学》
北大核心
2021年第11期692-696,共5页
Chinese Journal of Gastroenterology
基金
国家自然科学基金面上项目(81573737,82074213)。
关键词
胃食管反流病
食管菌群
影响因素
益生菌
Gastroesophageal Reflux Disease
Esophageal Flora
Influencing Factors
Probiotics
作者简介
通信作者:唐艳萍,Email:cb1699@sina.com。
