摘要
以往认为溃疡性结肠炎(UC)病因不清,中西医均难以治愈,有的甚至认为UC是终身疾病,不能根治。笔者通过回顾性研究,发现多数UC活动期患者C反应蛋白、中性粒细胞百分比与血小板均升高,血清1,3-β-D-葡聚糖及内毒素水平均不同程度增高,且与UC病情严重程度呈正相关,因此,首先提出UC是由真菌尤其是白念珠菌感染引起的侵袭性真菌病,同时伴有不同程度内毒素血症,UC诱因或影响因素包括不良饮食及情绪、劳累、手术、环境因素及使用某种药物等。
In the past, it was thought that the cause of ulcerative colitis(UC) was unclear, and it was difficult to cure in traditional Chinese and Western medicine, and some even thought that UC was a lifelong disease that could not be cured. By retrospectively study, it was found that C-reactive protein, neutrophil percentage and platelet were all elevated in most UC cases,serum 1,3-β-D-glucan and endotoxin levels in active UC patients were increased to varying degrees, positively correlated with the severity of UC disease, Therefore, it is first proposed that UC is an invasive fungal disease caused by fungal especially Candida albicans infection, accompanied by varying degrees of endotoxemia, The causes or influencing factors of UC include poor diet and mood, tiredness, surgery, environmental factors, and the use of certain medications etc.
作者
鲁香凤
秦伟娜
耿运玲
LU Xiang-feng;QIN Wei-na;GENG Yun-ling(Department of Pathology,Dongzhimen Hospital,Beiing University of Chinese Medicine,Beiing 100700,China;Quality Control Office,Dongzhimen Hospital,Beiing University of Chinese Medicine,Beijing 100700,China;PhD Student,Dongzhimen Hospital,Beiing University of Chinese Medicine,Beijing 100700,China)
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2022年第10期6140-6144,共5页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
北京中医药大学东直门医院自发课题(No.2022DZMEC-309-01)。
关键词
溃疡性结肠炎
侵袭性真菌病
白念珠菌
影响因素
Ulcerative colitis(UC)
Invasive fungal disease(IFD)
Candida albicans
Influencing factors
作者简介
通信作者:鲁香凤,北京市东城区海运仓5号北京中医药大学东直]医院,邮编:100700,电话:010-84013198,E-mail:xiangfenglu@163.com。
