摘要
目的:探讨孕妇血脂多糖结合蛋白(LBP)、分泌型磷脂酶A2(sPLA2)及白细胞介素8(IL-8)水平变化及诊断胎膜早破合并宫内感染价值.方法:回顾性收集2020年1月-2021年1月本院诊治的胎膜早破合并宫内感染患者98例(病例组),单纯胎膜早破50例(胎膜早破组)、产前检查健康孕妇60例(对照组)临床资料,分析各组血LBP、sPLA2、IL-8水平变化及诊断胎膜早破合并宫内感染价值.结果:血LBP、sPLA2、IL-8水平在对照组(70.54±20.65 ng/ml、74.58±20.41ng/ml、7.84±0.80pg/ml),胎膜早破组(82.56±24.59ng/ml、121.25±26.04ng/ml、11.48±1.38 pg/ml),病例组(107.43±30.35ng/ml、150.22±25.41ng/ml、15.76±1.67pg/ml)依次升高,且病例组中未足月者高于足月者(均P<0.05);受试者工作特征曲线分析显示,预测胎膜早破合并宫内感染,血LBP的曲线下面积(AUC)0.797,灵敏度75.5%,特异度78.5%,截断值89.56ng/ml;sPLA2的AUC为0.839,灵敏度76.7%,特异度为79.9%,截断值为107.84ng/ml;IL-8的AUC为0.995,灵敏度为85.3%,特异度为86.6%,截断值为9.15pg/ml,3项联合检测时较单独检测特异度、准确度均较单独检测AUC为0.998,灵敏度(91.5%)、特异度(93.1%)、准确度(95.5%)更高(P<0.05).结论:胎膜早破合并宫内感染孕妇血LBP、sPLA2及IL-8表达异常升高,3项联合检测对胎膜早破合并宫内感染有较高的诊断价值.
Objective: To explore the changes of the levels of blood lipopolysaccharide binding protein(LBP), secretory phospholipase A2(sPLA2), and interleukin 8(IL-8) of pregnant women, and to study their values for diagnosing the premature rupture of membranes complicated with intrauterine infection of the women. Methods: The clinical data of 98 pregnant women with premature rupture of membranes complicated with intrauterine infection(in group A), 50 pregnant women with simple premature rupture of membranes(in group B), and 60 healthy pregnant women who underwent pregnancy examination(in group C) from January 2020 to January 2021 were collected retrospectively. The changes of the levels of serum LBP, sPLA2, and IL-8 of the women in the three groups were analyzed. The diagnostic value of LBP, sPLA2, and IL-8 levels of the women for their premature rupture of membranes complicated with intrauterine infection was also analyzed. Results: The levels of LBP, sPLA2, and IL-8 of the women in group C were 70.54±20.65 ng/ml, 74.58±20.41 ng/ml, and 7.84±0.80 pg/ml, respectively, those of the women in group B were 82.56±24.59 ng/ml, 121.25±26.04 ng/ml, and 11.48±1.38 pg/ml, respectively, and those of the women in group A were 107.43±30.35 ng/ml, 150.22±25.41 ng/ml, 15.76±1.67 pg/ml, respectively. The levels of LBP, sPLA2, and IL-8 of the women in group C, in group B, and in group A had increased gradually, and which of the women without full term of pregnancy in group A were significantly higher than those of the women with full term of pregnancy(all P<0.05).Receiver operating characteristic curve analysis showed that the area under the curve(AUC),the sensitivity,the specificity,and the cut-off value of the serum LBP level of the women for diagnosing their premature rupture of membranes complicated with intrauterine infection were 0.797,75.5%,78.5%,and 89.56ng/ml,respectively.The AUC,the sensitivity,the specificity,and the cut-off value of the serum sPLA2level of the women for diagnosing their premature rupture of membranes complicated with intrauterine infection were 0.839,76.7%,79.9%,and 107.84ng/ml,respectively.The AUC,the sensitivity,the specificity,and the cut-off value of the serum IL-8level of the women for diagnosing their premature rupture of membranes complicated with intrauterine infection were 0.995,85.3%,86.6%,and 9.15pg/ml,respectively.The AUC,the sensitivity,the specificity,and the accuracy of the combined of the levels of serum LBP,sPLA2,and IL-8of the women for diagnosing their premature rupture of membranes complicated with intrauterine infection were 0.998,91.5%,93.1%,and 95.5%,respectively,which were all significantly higher than those of the serum LBP level,sPLA2level,or IL-8level alone(P<0.05).Conclusion:The expressions levels of blood LBP,sPLA2,and IL-8of the pregnant women with the premature rupture of membranes complicated with intrauterine infection increase abnormally.The combined of the levels of serum LBP,sPLA2,and IL-8of the women for diagnosing their premature rupture of membranes complicated with intrauterine infection has higher value.
作者
芦金玲
姚升郊
刘娜
LU Jinling;YAO Shengjiao;LIU Na(The Sixth Hospital of Beijing,100007)
出处
《中国计划生育学杂志》
2022年第10期2378-2381,共4页
Chinese Journal of Family Planning
关键词
胎膜早破
宫内感染
脂多糖结合蛋白
分泌型磷脂酶A2
白细胞介素8
诊断价值
Premature rupture of membranes
Intrauterine infection
Lipopolysaccharide binding protein
Secretory phospholipase A2
Interleukin 8
Diagnostic value
