摘要
目的探讨急性时相反应蛋白及促炎因子在支气管哮喘患者中的检测价值。方法选取2021年1-11月在该院治疗的150例支气管哮喘患者作为研究对象,根据哮喘严重程度分为轻度组(50例)、中度组(50例)和重度组(50例),另选取同期50例体检健康者作为对照组。比较4组研究对象血清急性时相反应蛋白[C反应蛋白(CRP)、α1-酸性糖蛋白(α1-AG)、结合珠蛋白(Hp)]及促炎因子[白细胞介素(IL)-1β、IL-6、IL-8、肿瘤坏死因子-α(TNF-α)]水平,采用Spearman秩相关分析CRP、α1-AG、Hp,以及IL-1β、IL-6、IL-8、TNF-α与支气管哮喘严重程度的关系。结果轻度组、中度组和重度组CRP、α1-AG、Hp,以及IL-1β、IL-6、IL-8、TNF-α水平均明显高于对照组,重度组明显高于轻度组和中度组,中度组明显高于轻度组,差异均有统计学意义(P<0.05)。Spearman秩相关分析结果显示,CRP、α1-AG、Hp,以及IL-1β、IL-6、IL-8、TNF-α与支气管哮喘严重程度均呈正相关(P<0.05)。结论支气管哮喘患者血清急性时相反应蛋白及促炎因子表达水平相对较高,并且与支气管哮喘严重程度密切相关。
Objective To investigate the detection value of acute phase reaction proteins and proinflammatory factors in patients with bronchial asthma.Methods A total of 150 cases of bronchial asthma from January to November 2021 were selected as research objects,and according to the severity of asthma,they were divided into mild group(50 cases),moderate group(50 cases)and severe group(50 cases).Another 50 healthy persons who underwent physical examination were chosen as the control group.The serum acute phase reaction proteins[C-reactive protein(CRP),α1-acid glycoprotein(α1-AG)and haptoglobin(Hp)]and proinflammatory factors[interleukin(IL)-1β,IL-6,IL-8 and tumor necrosis factor-α(TNF-α)]of four groups were compared,and Spearman rank correlation was used to analyze the relationship between CRP,α1-AG,Hp,IL-1β,IL-6,IL-8 and TNF-αand the severity of bronchial asthma.Results The levels of CRP,α1-AG,Hp,IL-1β,IL-6,IL-8 and TNF-αin mild group,moderate group and severe group were significantly higher than those in control group,those in severe group were significantly higher than those in mild group and moderate group,those in moderate group were significantly higher than those in mild group,and the differences were statistically significant(P<0.05).Spearman rank correlation results showed that the serum levels of CRP,α1-AG,Hp,IL-1β,IL-6,IL-8 and TNF-αwere positively correlated with the severity of bronchial asthma(P<0.05).Conclusion The expression levels of acute phase reaction proteins and proinflammatory factors in patients with bronchial asthma are relatively high,and they all have close relationship with the severity of bronchial asthma.
作者
李晶
陈琼娣
崔琼
韩亮
李远珍
陈远东
马玲娣
LI Jing;CHEN Qiongdi;CUI Qiong;HAN Liang;LI Yuanzhen;CHEN Yuandong;MA Lingdi(Department of Clinical Laboratory,the Third People′s Hospital of Huizhou,Huizhou,Guangdong 516002,China)
出处
《国际检验医学杂志》
CAS
2022年第20期2531-2534,共4页
International Journal of Laboratory Medicine
基金
广东省惠州市科技计划项目(2020Y249)。
关键词
急性时相反应蛋白
促炎因子
支气管哮喘
疾病严重程度
acute phase reaction proteins
proinflammatory factors
bronchial asthma
severity of disease
作者简介
李晶,女,技师,主要从事临床检验诊断学方面的研究;通信作者:马玲娣,E-mail:lingdimawsh@126.com。
