摘要
BACKGROUND Castleman’s disease(CD),also known as vascular follicular lymphadenopathy is a rare proliferative disease of lymphoid tissue of unknown etiology that is clinically classified as unicentric CD(UCD) or multicentric CD(MCD) depending on lymph node involvement.At present,idiopathic MCD(iMCD) is treated with interleukin-6 inhibitors,but some patients have poor clinical outcomes.This paper reports on a case of iMCD that achieved a good therapeutic effect after treatment with glucocorticoids combined with tofacitinib.The relevant data are summarized and reported below.CASE SUMMARY This paper reports on a case of MCD in a 49-year-old female with persistent peritoneal effusion as the first manifestation and combined with multiple lymphadenopathies.Lymph node biopsy showed Castleman’s disease-like changes.The ascites subsided after treatment with glucocorticoids and tofacitinib,indicating that the treatment was effective.CONCLUSION The combination of glucocorticoids with tofacitinib is an effective regimen for the treatment of CD.
作者简介
Xiao-Rui Liu,ORCID number:0000-0003-1518-8811;Corresponding author:Mei Tian,PhD,Chief Doctor,Department of Rheumatology and Immunology,Affiliated Hospital of Zunyi Medical University,No.149 Dalian Road,Huichuan District,Zunyi 563003,Guizhou Province,China.348820517@qq.com ,ORCID number:0000-0002-1633-2988.
