摘要
目的:探究低分子肝素钠对急性心肌梗死患者的影响。方法:选取2019年12月-2021年3月福建省立医院92例急性心肌梗死患者为研究对象。根据随机数字表法将其分为对照组和观察组,每组46例。两组均采用阿替普酶进行治疗,对照组给予肝素钠注射液,观察组则给予低分子肝素钠注射液。比较两组临床疗效、首次ST段回落>50%时间、胸痛缓解时间、不良反应、治疗前及治疗1、3 d抗Ⅹa活性、APTT及血小板活化指标。结果:观察组临床总有效率显著高于对照组(P<0.05)。观察组首次ST段回落>50%时间及胸痛缓解时间均显著优于对照组(P<0.05)。观察组不良反应发生率显著低于对照组(P<0.05)。治疗1、3 d,观察组抗Ⅹa活性显著高于对照组,APTT显著长于对照组(P<0.05)。治疗1、3 d,观察组CD41、CD62P及CD63均显著低于对照组(P<0.05)。结论:低分子肝素钠在急性心肌梗死患者中的应用效果较好,且可显著改善抗Ⅹa活性、APTT及血小板活化,因此在急性心肌梗死患者中的应用价值较高。
Objective:To investigate effect of Low Molecular Weight Heparin Sodium on patients with acute myocardial infarction.Method:A total of 92 patients with acute myocardial infarction in Fujian Provincial Hospital from December 2019 to March 2021 were selected as the research objects.According to the method of random number table,they were divided into control group and observation group,with 46 cases in each group.Both groups were treated with Alteplase,the control group was given Heparin Sodium Injection,and the observation group was given Low Molecular Weight Heparin Sodium Injection.The clinical efficacy,first ST segment fall >50% time,chest pain relief time,adverse reactions,anti Ⅹa activity,APTT and platelet activation indexes before treatment and 1 and 3 d of treatment were compared between the two groups.Result:The total clinical effective rate of the observation group was significantly higher than that of the control group (P<0.05).The first ST segment fall >50% time and chest pain relief time in the observation group were significantly better than those in the control group (P<0.05).The incidence of adverse reactions in the observation group was significantly lower than that in the control group (P<0.05);1 and 3 d of treatment,the anti Ⅹa activity of the observation group was significantly higher than that of the control group,and APTT was significantly longer than that of the control group (P<0.05);1 and 3 d of treatment,CD41,CD62P and CD63 in the observation group were significantly lower than those in the control group (P<0.05).Conclusion:The application effect of Low Molecular Weight Heparin Sodium in patients with acute myocardial infarction is good,and it can significantly improve anti Ⅹa activity,APTT and platelet activation,so it has high application value in patients with acute myocardial infarction.
作者
窦敏
曹鹏驹
林一
王颖
DOU Min;CAO Pengju;LIN Yi;WANG Ying(Fujian Provincial Hospital,Fuzhou 350001,China;不详)
出处
《中外医学研究》
2022年第24期148-151,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
低分子肝素钠注射液
急性心肌梗死
抗a活性
APTT
血小板活化
Low Molecular Weight Heparin Sodium Injection
Acute myocardial infarction
AntiⅩa activity
APTT
Platelet activation
