摘要
目的:探讨甲苯磺酸瑞马唑仑联合艾司氯胺酮注射液对无痛结肠镜检查患者的影响。方法:选取山西省肿瘤医院2020年9月-2021年9月收治的100例无痛结肠镜检查患者。根据随机数字表法将其分为联合组和对照组,各50例。对照组给予盐酸艾司氯胺酮注射液,联合组在对照组基础上加用注射用甲苯磺酸瑞马唑仑。比较两组麻醉效果,检查前和检查后1 h临床体征,镇静起效时间和苏醒质量,检查前,检查后1、3、6 h的认知功能,不良反应。结果:联合组离室时间、结肠镜检查时间均短于对照组,清醒时间早于对照组(P<0.05)。检查后1 h,联合组心率(heart rate,HR)、平均动脉压(mean arterial pressure,MAP)均低于对照组(P<0.05),血氧饱和度(SpO_(2))明显高于对照组(P<0.05)。联合组镇静起效时间、定向力恢复时间均早于对照组,Steward苏醒评分高于对照组(P<0.05)。检查后1、3、6 h,联合组简易精神状态检查量表(the mini-mental state examination,MMSE)评分均高于对照组(P<0.05)。联合组不良反应发生率低于对照组(P<0.05)。结论:甲苯磺酸瑞马唑仑联合艾司氯胺酮可安全应用于无痛结肠镜患者诊疗中,效果较好,值得临床推广。
Objective:To investigate the effect of Remimazolam Tosilate combined with Esketamine on patients with painless colonoscopy examination.Method:A total of 100 patients with painless colonoscopy examination admitted to Shanxi Provincial Cancer Hospital from September 2020 to September 2021 were selected.According to the random number table method,they were divided into combined group and control group,with 50 cases in each group.The control group was given the Esketamine Hydrochloride Injection,and the combined group added the application of Remimazolam Tosilate for Injection on the basis of the control group.The anesthetic effect,clinical signs before and 1 h after examination,sedation onset time and awakening quality,cognitive function before and 1,3 and 6 h after the examination,and adverse reactions of the two groups were compared.Result:The time of leaving the room and colonoscopy in the combined group were shorter than those in the control group,and the awake time was earlier than that in the control group(P<0.05).One hour after the examination,the heart rate(HR)and mean arterial pressure(MAP)of the combined group were lower than those of the control group(P<0.05),and the blood oxygen saturation(SpO_(2))was significantly higher than that of the control group(P<0.05).The sedation onset time and the recovery time of directional force in the combined group were earlier than those in the control group,and the Steward recovery score was higher than that in the control group(P<0.05).The mini-mental state examination(MMSE)scores of the combined group were higher than those of the control group 1,3 and 6 h after the examination(P<0.05).The incidence of adverse reactions in the combined group was lower than that in the control group(P<0.05).Conclusion:Remimazolam Tosilate combined with Esketamine can be safely used in the diagnosis and treatment of painless colonoscopy patients,with good effect,which is worthy of clinical promotion.
作者
白日虹
高海平
康金秀
BAI Rihong;GAO Haiping;KANG Jinxiu(Shanxi Provincial Cancer Hospital,Taiyuan 030013,China)
出处
《中外医学研究》
2022年第27期120-123,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
作者简介
通信作者:康金秀。
