摘要
目的探讨下肢动脉硬化性闭塞症(LEASO)介入术后发生支架内再狭窄(ISR)的危险因素。方法计算机检索中国知网、万方数据库、中国生物医学文献数据库、维普中文科技期刊数据库、PubMed、the Cochrane Library、Embase、Web of Science、临床试验注册中心数据库中关于LEASO介入术后发生ISR的危险因素相关研究。运用纽卡斯尔-渥太华量表(NOS)、Revman 5.3、Stata 14.0统计软件进行文献质量评价和Meta分析。结果共纳入24篇高质量文献,Meta分析、敏感性分析、偏倚检验结果显示,高CRP水平(OR=1.82,95%CI:1.44~2.31)、高LDL-C水平(OR=3.24,95%CI:2.58~4.07)均是LEASO介入术后发生ISR的危险因素,且两者均无发表偏倚,而糖尿病、吸烟作为LEASO介入术后发生ISR的危险因素均存在发表偏倚。结论高CRP、LDL-C水平均是LEASO介入术后发生ISR的危险因素,应积极控制患者的LDL-C水平,定期复查CRP,及时给予预防措施,对降低LEASO介入术后ISR的发生率具有重要意义。
Objective To explore the risk factors of in-stent restenosis(ISR)after interventional therapy in lower extremity arteriosclerosis obliterans(LEASO).Method The relevant studies on the risk factors of ISR after LEASO intervention in the databases of CNKI,Wanfang database,China Biomedical Literature database,VIP,PubMed,the Cochrane Library,Embase,Web of Science and clinical trial registration center database were searched by computer.The Newcastle-Ottawa-scale(NOS),Revman 5.3 and Stata 14.0 statistical software were used for literature quality evaluation and Meta-analysis.Result A total of 24 high-quality literatures were included.The results of Meta-analysis,sensitivity analysis and bias test showed that high CRP level(OR=1.82,95%CI:1.44-2.31)and high LDL-C level(OR=3.24,95%CI:2.58-4.07)were risk factors for ISR after LEASO intervention,and neither of them had publication bias,while diabetes and smoking as risk factors for ISR after LEASO intervention had publication bias.Conclusion High levels of CRP and LDL-C are the risk factors for ISR after LEASO intervention.It is of great significance to actively control the LDL-C level of patients,regularly review CRP indicators,and give preventive measures in time to reduce the incidence of ISR after LEASO intervention.
作者
苏晓雪
袁晓庆
赵士博
杨桂楠
杜刘念博
欧明辉
Su Xiaoxue;Yuan Xiaoqing;Zhao Shibo;Yang Guinan;Du Liunianbo;Ou Minghui(Department of Vascular Surgery,Qingdao Municipal Hospital Affiliated to Qingdao University,Qingdao 266000,Shandong,China;Qingdao Medical College of Qingdao University,Qingdao 266000,Shandong,China;Department of Urologic Surgery,Qingdao Municipal Hospital Affiliated to Qingdao University,Qingdao 266000,Shandong,China)
出处
《血管与腔内血管外科杂志》
2022年第8期926-934,共9页
Journal of Vascular and Endovascular Surgery
基金
国家自然科学基金(81871187)。
作者简介
苏晓雪,主要从事血管外科疾病的临床研究,青岛大学附属青岛市市立医院;通信作者:欧明辉,主任医师,E-mail:oumhmed@sina.cn。
