摘要
目的探讨炔雌醇环丙孕酮片联合左炔诺孕酮宫内释放系统(LNG-Ius)治疗排卵障碍性异常子宫出血的效果。方法选取2019年1月至2021年1月吉安市中心人民医院妇产科收治的160例排卵障碍性异常子宫出血患者作为研究对象,按照随机数字表法将其分为对照组(80例)与观察组(80例)。对照组患者采用LNG-Ius治疗,观察组患者采用炔雌醇环丙孕酮片联合LNG-Ius治疗。比较两组患者的临床治疗效果、月经失血评分及性激素水平。结果观察组患者的临床治疗总有效率高于对照组,差异有统计学意义(P<0.05)。两组患者治疗前的月经失血评分比较,差异无统计学意义(P>0.05);观察组患者治疗后的月经失血评分低于对照组,差异有统计学意义(P<0.05)。治疗前,两组患者的雌二醇(E_(2))、促黄体生成素(LH)、促卵泡生成素(FSH)水平比较,差异无统计学意义(P>0.05);治疗后,观察组患者的E_(2)、LH、FSH水平低于对照组,差异有统计学意义(P<0.05)。结论针对排卵障碍性异常子宫出血患者,采取炔雌醇环丙孕酮片联合LNG-Ius治疗有较佳的效果,可有效改善患者的性激素水平,利于患者病情的恢复。
Objective To investigate the effect of Ethinyl Estradiol Cyproterone Tablets combined with levonorgestrel-releasing intrauterine system(LNG-Ius)in the treatment of ovulatory abnormal uterine bleeding.Methods From January 2019 to January 2021,160 patients with ovulatory abnormal uterine bleeding who were admitted to the Department of Obstetrics and Gynecology of Ji′an Central People′s Hospital were selected as the research objects,they were divided into the control group(80 cases)and the observation group(80 cases)according to the random number table method.The control group was treated with LNG-Ius,and the observation group was treated with Ethinyl Estradiol Cyproterone Tablets combined with LNG-Ius.The clinical treatment effect,menstrual blood loss score and sex hormone levels were compared between the two groups.Results The total effective rate of clinical treatment in the observation group after treatment was higher than that in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the menstrual blood loss score between the two groups before treatment(P>0.05).The menstrual blood loss score in the observation group after treatment was lower than that in the control group,and the difference was statistically significant(P<0.05).Before treatment,there were no statistical differences in the levels of estradiol(E_(2)),luteinizing hormone(LH)and follicle-stimulating hormone(FSH)between the two groups(P>0.05).After treatment,the E_(2),LH and FSH levels of the observation group were lower than those of the control group,and the differences were statistically significant(P<0.05).Conclusion For patients with ovulatory abnormal uterine bleeding,the combination of Ethinyl Estradiol Cyproterone Tablets combined with LNG-Ius has a better therapeutic effect,which can effectively improve the level of sex hormones and is conducive to the recovery of the patients′condition.
作者
罗春艳
夏桥
陈虹
LUO Chunyan;XIA Qiao;CHEN Hong(Department of Obstetrics and Gynecology,Ji′an Central People′s Hospital,Jiangxi Province,Ji′an 343000,China;Department of Obstetrics and Gynecology,People′s Hospital of Yanshan County,Shangrao City,Jiangxi Province,Yanshan 334000,China)
出处
《中国当代医药》
CAS
2022年第27期100-103,共4页
China Modern Medicine
基金
江西省卫生健康委科技计划项目(202212823)。
关键词
炔雌醇环丙孕酮片
左炔诺孕酮宫内缓释系统
排卵障碍性异常子宫出血
性激素水平
Ethinyl Estradiol Cyproterone Tablets
Levonorgestrel-releasing intrauterine system
Ovulatory abnormal uterine bleeding
Sex hormone level
