摘要
目的探讨CT灌注成像结合肿瘤标志物对孤立性肺结节(SPN)良恶性的鉴别诊断价值。方法纳入SPN患者120例,其中经手术或穿刺活检证实良性结节43例(良性组)、恶性结节77例(恶性组),比较两组CT灌注参数、血清肿瘤标志物,并分析以上指标联合鉴别SPN良恶性的价值。结果恶性组BF、BV、PS、MST、MSD、PH、R均高于良性组,MTT、TTP较良性组延长(P<0.05);恶性组血清CEA、CA125、NSE、CyFRA21-1水平高于良性组,差异有显著性(P<0.05);CT灌注成像与血清肿瘤标志物联合判断SPN恶性的价值最佳,敏感度为92.21%,特异度为81.40%,准确度为88.33%,曲线下面积为0.868。结论CT灌注成像联合血清肿瘤标志物检测对SPN良恶性有较好鉴别价值,能明显提高诊断敏感度、特异度、准确度,值得在临床推广实践。
Objective To investigate the value of CT perfusion imaging combined with tumor markers in differential diagnosis of benign and malignant solitary pulmonary nodules(SPN).Methods A total of 120 patients with SPN were included in the study,including 43 patients with benign nodules(benign group)and 77 patients with malignant nodules(malignant group)confirmed by surgery or biopsy.CT perfusion parameters and serum tumor markers were compared between the two groups.Value of these indicators in joint differential diagnosis of benign and malignant SPN was analyzed.Results BF,BV,PS,MST,MSD,PH and R of malignant group were larger than those of the benign group,and MTT and TTP were longer than those of the benign group(P<0.05).Serum CEA,CA125,NSE and CyFRA21-1 levels in the malignant group were higher than those in the benign group(P<0.05).The value of CT perfusion imaging combined with serum tumor markers was the highest in differential diagnosis of benign and malignant SPN.The sensitivity,specificity,accuracy and area under the curve were 92.21%,81.40%,88.33%and 0.868,respectively.Conclusion CT perfusion imaging combined with serum tumor markers can significantly improve the diagnostic sensitivity,specificity and accuracy for benign and malignant SPN.
作者
潘广松
覃广谋
林建华
韦岑
胡奇毅
彭昌丽
潘晚
谢尚勐
PAN Guang-song;QIN Guang-mou;LIN Jian-hua;WEI Cen;HU Qi-yi;PENG Chang-li;PAN Wan;XIE Shang-meng(Department of Radiology,Laibin People's Hospital,Laibin 546100,Guangxi Province,China)
出处
《中国CT和MRI杂志》
2022年第10期43-45,共3页
Chinese Journal of CT and MRI
基金
广西壮族自治区卫生健康委员会自筹经费项目(Z20200339)。
关键词
CT灌注成像
肿瘤标志物
孤立性肺结节
良恶性
CT Perfusion Imaging
Tumor Marker
Solitary Pulmonary Nodule
Benign and Malignant
作者简介
第一作者/通讯作者:潘广松,男,副主任医师,主要研究方向:肺部疾病影像诊断。E-mail:pgs.2006@163.com。
