摘要
目的探讨急性心肌梗死(AMI)患者接受经皮冠状动脉介入(PCI)术治疗后血清高敏-C反应蛋白(hs-CRP)、可溶性细胞间黏附分子-1(sICAM-1)水平,并分析血清hs-CRP、sICAM-1水平与AMI患者PCI治疗后心肌无复流的关系。方法选取2020年1月至2021年9月在柘城中医院接受PCI治疗的152例AMI患者作为研究对象,患者均在接受PCI治疗后即刻测定血清hs-CRP、sICAM-1水平,并于治疗后3 d内接受冠状动脉造影评估。依据TIMI血流分级标准评估AMI患者心肌无复流的发生状况,分析AMI患者PCI治疗后血清hs-CRP、sICAM-1水平与心肌无复流之间的关系。结果依据TIMI血流分级标准,152例AMI患者接受PCI治疗后22例(14.47%)发生心肌无复流;发生心肌无复流的AMI患者的血清hs-CRP、sICAM-1水平高于未发生患者(P<0.05);经点二列相关性分析显示,AMI患者PCI治疗后血清hs-CRP、sICAM-1水平与心肌无复流呈正相关(r>0,P<0.05)。结论AMI患者接受PCI治疗后存在心肌无复流发生风险,且血清hs-CRP、sICAM-1水平与心肌无复流呈正相关。
Objective To investigate the levels of serum hypersensitive C-reactive protein(hs-CRP)and soluble intercellular adhesion molecule-1(sICAM-1)in patients with acute myocardial infarction(AMI)after percutaneous coronary intervention(PCI),and to analyze the relationship between the levels of serum hs-CRP and sICAM-1 and myocardial no reflow after PCI in patients with AMI.Methods A total of 152 patients with AMI who underwent PCI in Zhecheng Hospital of Traditional Chinese Medicine from January 2020 to September 2021 were selected as the research subjects.The levels of serum hs-CRP and sICAM-1 of patients were measured immediately after PCI.The patients were evaluated by coronary angiography within 3 days after treatment.According to TIMI blood flow classification standard,the incidence of myocardial non reflow in AMI patients was evaluated,and the relationships between serum hs-CRP,sICAM-1 levels and myocardial non reflow in AMI patients after PCI were analyzed.Results According to TIMI blood flow classification,22 cases(14.47%)of 152 patients with AMI had no myocardial reflow after PCI.The levels of serum hs-CRP and sICAM-1 in patients with AMI without myocardial reflow were higher than those in patients without myocardial reflow(P<0.05).The point two column correlation analysis showed that the levels of serum hs-CRP and sICAM-1 in patients with AMI after PCI were positively correlated with myocardial no reflow(r>0,P<0.05).Conclusion There is a risk of myocardial non reflow in patients with AMI after PCI.The levels of serum hs-CRP and sICAM-1 were positively correlated with myocardial no reflow.
作者
高艳萍
陈强
GAO Yanping;CHEN Qiang(Department of Laboratory,Zhecheng Hospital of Traditional Chinese Medicine,Shangqiu 476200,China)
出处
《河南医学研究》
CAS
2022年第18期3379-3382,共4页
Henan Medical Research
关键词
急性心肌梗死
经皮冠状动脉介入术
血清高敏-C反应蛋白
可溶性细胞间黏附分子-1
心肌无复流
acute myocardial infarction
percutaneous coronary intervention
serum hypersensitive C-reactive protein
soluble intercellular adhesion molecule-1
myocardial no reflow
