摘要
目的分析内皮抑素(ES)、血小板反应蛋白-1(TSP-1)水平与慢性心力衰竭的关系,以为该病严重程度的评估提供参考依据。方法从2018年3月至2019年3月本院接收的慢性心力衰竭患者中抽选90例,根据左室射血分数(LVEF)将其分为射血分数降低组、射血分数中间值组以及射血分数保留组,各30例。另抽选同期在本院住院治疗的30例心功能正常患者作为对照组。测定并比较四组的心功能指标[左室收缩末期内径(LVESD)、左室舒张末期内径(LVEDD)、N-末端脑钠肽前体(NT-proBNP)]及ES、TSP-1、血管内皮生长因子(VEGF)水平,分析各指标的相关性。结果LVESD、LVEDD及NT-proBNP水平的变化趋势为射血分数降低组>射血分数中间值组>射血分数保留组>对照组,差异具有统计学意义(P<0.05)。ES、TSP-1和VEGF水平的变化趋势为射血分数降低组>射血分数中间值组>射血分数保留组>对照组,差异具有统计学意义(P<0.05)。Pearson相关性分析结果显示,ES与LVEF呈负相关,与LVEDD、NT-proBNP、TSP-1、VEGF呈正相关(P<0.05);TSP-1与LVEF呈负相关,与LVEDD、NT-proBNP呈正相关(P<0.05)。结论ES、TSP-1及VEGF参与慢性心力衰竭的发生及发展过程,可准确反映患者病情严重程度,具有一定的临床指导价值。
Objective To analyze the relationship between the levels of endostatin(ES),thrombospondin-1(TSP-1)and chronic heart failure,so as to provide reference for the evaluation of the severity of this disease.Methods A total of 90 patients with chronic heart failure admitted in our hospital from March 2018 to March 2019 were selected and divided into ejection fraction decreased group,ejection fraction intermediate value group and ejection fraction retention group according to the left ventricular ejection fraction(LVEF),with 30 cases in each group.Another 30 patients with normal cardiac function hospitalized in our hospital in the same period were selected as control group.The cardiac function indexes[left ventricular end systolic diameter(LVESD),left ventricular end diastolic diameter(LVEDD),N-terminal brain natriuretic peptide(NT-proBNP)]and the levels of ES,TSP-1 and vascular endothelial growth factor(VEGF)in the four groups were measured and compared,and the correlation of the indexes was analyzed.Results The change trend of LVESD,LVEDD and NT-proBNP level were as follows:the ejection fraction decreased group>the ejection fraction intermediate value group>the ejection fraction retention group>the control group,and the differences were statistically significant(P<0.05).The change trend of ES,TSP-1 and VEGF levels were as follows:the ejection fraction decreased group>the ejection fraction intermediate value group>the ejection fraction retention group>the control group,and the differences were statistically significant(P<0.05).The Pearson correlation analysis results showed that ES was negatively correlated with LVEF and positively correlated with LVEDD,NT-proBNP,TSP-1 and VEGF(P<0.05);TSP-1 was negatively correlated with LVEF and positively correlated with LVEDD and NT-proBNP(P<0.05).Conclusion ES,TSP-1 and VEGF involvs in the occurrence and development of chronic heart failure,and can accurately reflect the severity of patients'condition.It has certain clinical guiding value.
作者
张志芳
屈小会
ZHANG Zhifang;QU Xiaohui(the Fourth People's Hospital of Shaanxi,Xi'an 710043;the Second Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang 712000,China)
出处
《临床医学研究与实践》
2022年第27期15-18,共4页
Clinical Research and Practice
作者简介
张志芳(1970—),女,副主任医师,学士。研究方向:高血压、心力衰竭的相关研究;通讯作者:屈小会,E-mail:1121833978@qq.com.
