摘要
The hypoxic nature of tumours limits the efficiency of oxygen-dependent photodynamic therapy(PDT).Hence,in this study,indocyanine green(ICG)-loaded lipid-coated zinc peroxide(ZnO_(2))nanoparticles(ZnO_(2)@Lip-ICG)was constructed to realize tumour microenvironment(TME)-responsive self-oxygen supply.Near infrared light irradiation(808 nm),the lipid outer layer of ICG acquires sufficient energy to produce heat,thereby elevating the localised temperature,which results in accelerated ZnO_(2)release and apoptosis of tumour cells.The ZnO_(2)rapidly generates O_(2)in the TME(pH 6.5),which alleviates tumour hypoxia and then enhances the PDT effect of ICG.These results demonstrate that ZnO_(2)@Lip-ICG NPs display good oxygen self-supported properties and outstanding PDT/PTT characteristics,and thus,achieve good tumour proliferation suppression.
基金
supported by the National Natural Science Foundation of China (No. 81771002, 82071057 and 82000988)
作者简介
Corresponding authors:Wei Wang.E-mail addresses:weiwang@hust.edu.cn(W.Wang);Corresponding authors:Hongjun Xiao.E-mail addresses:xhjent_whxh@hust.edu.cn(H.J.Xiao);Nan Wu,These authors contributed equally to this work;Yaqin Tu,These authors contributed equally to this work;Guorun Fan,These authors contributed equally to this work。
