摘要
背景酒精中毒会引发酒精性肌病。目前,评价酒精性肌病的标志物有10种以上,但这些标志物的评价价值尚存争议。目的系统评价酒精性肌病相关炎性因子和氧化应激标志物水平的影响。方法检索维普网(VIP)、万方数据知识服务平台(Wanfang Data)、中国知网(CNKI)、Web of Science、PubMed、Embase、Cochrane Library等数据库,筛选关于酒精性肌病相关炎性因子和氧化应激标志物的动物干预研究,检索时间为1990-02-01至2021-08-31。采用RevMan 5.4.1进行Meta分析。结局指标包括还原型谷胱甘肽(GSH)、丙二醛(MDA)、胰岛素样生长因子1(IGF-1)及白介素6(IL-6)mRNA表达水平。结果最终纳入17项动物干预试验,Meta分析结果表明,试验组IGF-1 mRNA表达水平〔SMD=-3.09,95%CI(-5.75,-0.43),P=0.02〕和GSH水平〔SMD=-4.20,95%CI(-6.24,-2.17),P<0.00001〕低于对照组;试验组IL-6 mRNA表达水平〔SMD=3.75,95%CI(2.93,4.57),P<0.00001〕和MDA水平〔SMD=0.97,95%CI(0.64,1.29),P<0.00001〕高于对照组。结论发生酒精性肌病时IGF-1 mRNA表达水平和GSH水平降低,IL-6 mRNA表达水平和MDA水平升高。
Background Alcoholism can lead to alcoholic myopathy.Although there are over ten biomarkers used to evaluate this disease,their diagnostic value remains controversial.Objective To systematically evaluate the effects of alcoholic myopathy on levels of relevant inflammatory factors and oxidative stress markers.Methods The VIP Database for Chinese Technical Periodicals,Wanfang Data Knowledge Service Platform,China National Knowledge Infrastructure,Web of Science,PubMed,Embase and Cochrane Library databases were searched for animal intervention studies on inflammatory factors and oxidative stress markers in alcoholic myopathy from February 1,1990 to August 31,2021 to retrieve.RevMan 5.4.1 was used for Meta-analysis.Outcome measures included reduced glutathione(GSH)and malondialdehyde(MDA)levels as well as the mRNA expression levels of insulin-like growth factor 1(IGF-1)and interleukin 6(IL-6).Results Ultimately,17 animal interventionstudies were included,and the results of Meta-analysis showed that the levels of IGF-1 mRNA expression〔SMD=-3.09,95%CI(-5.75,-0.43),P=0.02〕and GSH levels〔SMD=-4.20,95%CI(-6.24,-2.17),P<0.00001〕in the experimental group were lower than those in the control group.The levels of IL-6 mRNA expression〔SMD=3.75,95%CI(2.93,4.57),P<0.00001〕and MDA levels〔SMD=0.97,95%CI(0.64,1.29),P<0.00001〕were higher in the experimental group than those in the control group.Conclusion Animals with alcoholic myopathy show decreased IGF-1 mRNA expression and GSH levels but increased IL-6 mRNA expression and MDA levels.
作者
汪楠
Oleksandr Motuziuk
Iryna Mishchenko
周颖婷
WANG Nan;OLEKSANDR Motuziuk;IRYNA Mishchenko;ZHOU Yingting(Biomedical Research and Evidence-Based Center,Lesya Ukrainka Volyn National University,Lutsk 43025,Ukraine;Department of basic medicine,Jiangsu Vocational College of Medicine,Yancheng 224000,China;Volyn Medical Institute,Lutsk 43025,Ukraine)
出处
《中国全科医学》
CAS
北大核心
2022年第33期4123-4129,共7页
Chinese General Practice
关键词
肌病
慢性酒精性肌病
氧化应激
炎性因子浸润
系统评价
META分析
Myopathy
Chronic alcoholic myopathy
Oxidative stress
Inflammatory factor infiltration
Systematic evaluation
Meta analysis
作者简介
通信作者:Oleksandr Motuziuk,副教授,博士生导师,E-mail:cmoplutsk@gmail.com。
