摘要
对硝唑尼特合成中产生的副产物进行结构确证并推测其产生机理。采用高分辨质谱、核磁共振和红外光谱分析等技术对其进行了表征,副产物为2-乙酰氨基-5-硝基噻唑。副产物的结构确证有助于进一步优化硝唑尼特的合成工艺。
To confirm the structure of by-product produced in the synthesis of nitazoxanide and speculate its production mechanism,the structure was confirmed by high resolution mass spectrometry,nuclear magnetic resonance and infrared spectroscopy.The chemical structure of by-product was confirmed as 2-acetylamino-5-nitrothiazole.The confirmation of the structure of by-product can helps further optimize the synthesis process of nitazoxanide.
作者
王汝金
朱建德
王米
王霄旸
杨帆帆
张可煜
费陈忠
刘迎春
王春梅
薛飞群
张丽芳
Wang Rujin;Zhu Jiande;Wang Mi;Wang Xiaoyang;Yang Fanfan;Zhang Keyu;Fei Chenzhong;Liu Yingchun;Wang Chunmei;Xue Feiqun;Zhang Lifang(Key Laboratory of Veterinary Chemical Drugs and Pharmaceutics,Ministry of Agriculture and Rural Affairs,Shanghai Veterinary Research Institute,Chinese Academy of Agricultural Sciences,,Shanghai 200241,China)
出处
《化学世界》
CAS
2022年第4期199-202,共4页
Chemical World
作者简介
张丽芳,E-mail:twingzhang@shvri.ac.cn。
