摘要
右美托咪定(Dexmedetomidine,DTM)是一种高选择性ɑ2激动剂,它对ɑ2受体的选择性比为1620∶1,是可乐定的8倍。与阿片类药物和异丙酚等其他镇静剂不同。DTM具有显著的镇痛、镇静、抗炎、保护器官等药理学特征,并且其不良反应相对较少,无呼吸抑制,在临床中已经得到了广泛的应用。临床各科室根据手术特点选择麻醉方法,尽量减少麻醉期间对患者产生生理影响,降低手术本身对患者的不良刺激,减少手术和麻醉本身对患者的影响。此文对近年来DTM临床应用中的特点及不同剂量效果和不良反应报道进行了复习,以期为临床DTM的应用和剂量选择提供一定的参考。
Dexmedetomidine(DIM)is a highly selective drug ɑ2 agonist.The selectivity ratio of 2 receptor was 1620:1,which was 8 times that of clonidine.It is different frcm other sedatives such as cpioids and propofol.DIM has significant pharmacological characteristics such as analgesia,sedation,anti-inflanmatory and organ protection,and its side effects are relatively few and there is no respiratory depression It has been widely used in clinic.Clinical departments shall select anesthesia methods according to the characteristics of the operation,so as to minimize the physiological impact on patients during anesthesia,reduce the adverse stimulation of the operation itself on patients,and reduce the inpact of operation and anesthesia itself on patients.This paper reviews the characteristics of clinical application of DIM and the reports of different dose effects and adverse reactions in recent years,in order to provide sene reference for clinical application and dose selection of DTM.
作者
任晓静
Ren Xiaojing(Department of Anesthesiology,Baodi District People's Hospital,Tianjin 301800,China)
出处
《首都食品与医药》
2022年第16期12-15,共4页
Capital Food Medicine
关键词
右美托咪定
药理特点
不同剂量
麻醉
应用进展
Dexmedetomidine
Pharmacological characteristics
Different doses
Anesthesia
Application progress
