摘要
目的观察浒苔多糖对四氯化碳诱导的小鼠肝肾综合征保护作用。方法用四氯化碳诱导建立小鼠肝肾综合征模型,通过分析小鼠血脂、总抗氧化能力、肝肾功能及肝肾组织病理等变化,阐明浒苔多糖对小鼠肝肾综合征防治的有效性。结果浒苔多糖有效降低四氯化碳诱导的小鼠血脂水平,提高机体抗氧化能力,改善肝肾功能失调,减轻肝肾组织病变。结论浒苔多糖对四氯化碳诱导的小鼠肝肾综合征有良好的防治作用,可为今后的临床应用提供理论支持。
Objective To evaluate the protective effect of polysaccharides from Enteromorpha Prolifera(PEP)on mice with hepatorenal syndrome induced by carbon tetrachloride.Methods The mouse hepatorenal syndrome model was induced by carbon tetrachloride.The serum levels of lipid,total antioxidant capacity,liver and kidney function,pathological changes of liver and kidney were selected to clarity the effectiveness of PEP on hepatorenal syndrome in mice.Results PEP effectively lowed the serum levels of lipid,increased total antioxidant capacity,improved liver and kidney injury,and alleviated pathological changes of liver and kidney of mice induced by carbon tetrachloride.Conclusion PEP has the potent preventive effect on hepatorenal syndrome induced by carbon tetrachloride in mice,which provides theoretical support for future clinical application of PEP.
作者
赵晓娟
王珊珊
周佳燕
何越
周雅婷
杨秋茜
ZHAO Xiaojuan;WANG Shanshan;ZHOU Jiayan;HE Yue;ZHOU Yating;YANG Qiuxi(School of Pharmacy,Yancheng Teachers University,Yancheng 224007,China)
出处
《药学研究》
CAS
2022年第8期496-500,共5页
Journal of Pharmaceutical Research
基金
江苏省高等学校自然科学研究资助项目(No.20KJB310026)
大学生创新创业训练计划省级一般项目(No.202010324055Y)。
关键词
浒苔多糖
四氯化碳
肝肾综合征
Polysaccharides from Enteromorpha Prolifera
Carbon tetrachloride
Hepatorenal syndrome
作者简介
赵晓娟,女,博士研究生,讲师,研究方向:慢性代谢性肝脏疾病发病机制及药物干预机制研究,E-mail:zhaoxj@yctu.edu.cn。
