摘要
目的探究甲胎蛋白-系统性免疫炎症指数/白蛋白评分在早期肝癌射频消融术后预后评估中的价值。方法选取郑州大学第一附属医院2019年3月至2020年6月收治的69例经组织学病理活检确诊为原发性肝癌患者的临床资料进行回顾性分析,收集患者术前1周内中性粒细胞、单核细胞、淋巴细胞、血小板、白蛋白(ALB)、系统性免疫炎症指数(SII)、甲胎蛋白(AFP)、SII/ALB、AFP-SII/ALB评分,采用受试者工作特征曲线确定SII、SII/ALB最佳临界值,采用Kaplan-Meier法绘制疾病无进展生存期(PFS)曲线,并用log rank检验分析各组PFS的差异,利用COX风险回归模型分析影响PFS的危险因素。结果入组69例患者中随访期内64例复发,5例未复发。SII、SII/ALB、AFP-SII/ALB评分评估患者PFS的曲线下面积分别为0.800(95%CI:0.608~0.992)、0.797(95%CI:0.606~0.988)、0.850(95%CI:0.679~1.000),提示AFP-SII/ALB评分对PFS的诊断价值更高。AFP、SII、SII/ALB、AFP-SII/ALB评分与患者PFS有关(χ^(2)=9.574,P=0.003;χ^(2)=5.236,P=0.025;χ^(2)=5.753,P=0.019;χ^(2)=13.491,P<0.001)。AFP是影响患者PFS的独立危险因素(P=0.004)。结论对于早期肝癌患者,术前AFP-SII/ALB评分越低,应用射频消融术后的PFS越长。
Objective To explore the Prognostic value of alpha-fetoprotein-systemic immune inflammation index/albumin score in the patients with early hepatocellular carcinoma after radiofrequency ablation.Methods Retrospective analysis was performed on the clinical data of 69 patients diagnosed with primary hepatocellular carcinoma by histological pathological biopsy admitted to the First Affiliated Hospital of Zhengzhou University from March 2019 to June 2020.The neutrophils,monocytes,lymphocytes,platelets,albumin(ALB),systemic immune inflammation index(SII),alpha-fetoprotein(AFP),SII/ALB and AFP-SII/ALB score were collected within 1 week before surgery.The optimal critical values of SII and SII/ALB were determined by receiver operating characteristic(ROC)curve,the progression-free survival(PFS)curve was plotted by Kaplan-Meier,and the difference of PFS was tested by log-rank test.COX regression analysis was used to determine the risk factors of PFS.Results Of the 69 patients,64 patients relapsed and 5 patients did not relapse.The area under the curve determined by SII,SII/ALB and AFP-SII/ALB score were 0.800(95%CI:0.608-0.992)、0.797(95%CI:0.606-0.988)and 0.850(95%CI:0.679-1.000),AFP-SII/ALB score had more diagnostic value for PFS.AFP,SII,SII/ALB and AFP-SII/ALB score were related with PFS(χ^(2)=9.574,P=0.003;χ^(2)=5.236,P=0.025;χ^(2)=5.753,P=0.019;χ^(2)=13.491,P<0.001).and AFP was an independent risk factor for PFS(P=0.004).Conclusion For the early hepatocellular carcinoma,the lower the preoperative AFP-SII/ALB score,the longer the PFS survival after radiofrequency ablation.
作者
孟园园
李梦华
梁曦月
郭鹏
路太英
MENG Yuanyuan;LI Menghua;LIANG Xiyue;GUO Peng;LU Taiying(Department of Oncology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)
出处
《肿瘤基础与临床》
2022年第4期315-320,共6页
journal of basic and clinical oncology
基金
国家卫生计生委科技发展中心重大专项项目(2018ZX10303502)。
作者简介
孟园园(1995-),女,硕士,主要从事恶性肿瘤的综合治疗研究。E-mail:myydld@163.com;通信作者:路太英(1966-),女,博士,教授,主任医师,主要从事恶性肿瘤的综合治疗研究。E-mail:wanlucying@163.com。
