摘要
目的 探讨银丹心脑通软胶囊在急性心肌梗死(AMI)急诊经皮冠脉介入(PCI)术后的应用效果。方法 选取本院2019年3月至2021年3月收治的86例AMI患者作为研究对象,按照随机数字表法将其分为对照组与观察组,每组43例。对照组采用急诊PCI治疗,观察组在对照组基础上采用银丹心脑通软胶囊治疗。比较两组的治疗效果。结果观察组的治疗总有效率显著高于对照组,差异具有统计学意义(P<0.05)。治疗后,两组的丙二醛(MDA)、过氧化脂质(LPO)水平均低于治疗前,超氧化物歧化酶(SOD)水平均高于治疗前,且观察组优于对照组(P<0.05)。治疗后,两组的左前降支冠脉血流储备(CFVR)、左前降支舒张期血流峰值(DPV)及收缩期血流峰值(SPV)均高于治疗前,且观察组高于对照组(P<0.05)。治疗后,两组的微小RNA-29b(miR-29b)表达水平均高于治疗前,微小RNA-424(miR-424)表达水平均低于治疗前,且观察组优于对照组(P<0.05)。结论 银丹心脑通软胶囊用于AMI急诊PCI术后的临床效果显著,可有效改善机体氧化应激指标,提高冠脉血流情况,调节miR-29b与miR-424表达情况。
Objective To explore the application effect of Yindan Xinnaotong soft capsule after emergency percutaneous coronary intervention(PCI)for acute myocardial infarction(AMI).Methods A total of 86 patients with AMI treated in our hospital from March 2019 to March 2021 were selected as the research objects,and the patients were divided into control group and observation group according to the random number table method,with 43 cases in each group.The control group was treated with emergency PCI,and the observation group was treated with Yindan Xinnaotong soft capsule on the basis of the control group.The treatment effects were compared between the two groups.Results The total effective rate of treatment in the observation group was significantly higher than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of malondialdehyde(MDA)and lipid peroxide(LPO)in the two groups were lower than those before treatment,the level of superoxide dismutase(SOD)was higher than that before treatment,and those in the observation group were better than the control group(P<0.05).After treatment,the left anterior coronary flow velocity reserve(CFVR),left anterior diastolic peak velocity(DPV)and systolic peak velocity(SPV)in the two groups were higher than those before treatment,and those in the observation group were higher than the control group(P<0.05).After treatment,the expression level of microRNA-29b(miR-29b)in both groups was higher than that before treatment,the expression level of microRNA-424(miR-424)was lower than that before treatment,and those in the observation group were better than the control group(P<0.05).Conclusion Yindan Xinnaotong soft capsule in AMI after emergency PCI has a significant clinical effect,it can effectively improve the body's oxidative stress indexes,improve coronary blood flow,and regulate the expression of miR-29b and miR-424.
作者
宋锋超
王烨
张欢
SONG Fengchao;WANG Ye;ZHANG Huan(Shangzhou District People's Hospital,Shangluo 726000;Shangluo International Medical Center Hospital,Shangluo 726000;the Second Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang 712000,China)
出处
《临床医学研究与实践》
2022年第25期117-120,共4页
Clinical Research and Practice
基金
陕西省中医药管理局2017—2018年度中医药科研课题(No.LCPT081)。
关键词
急性心肌梗死
经皮冠脉介入
银丹心脑通软胶囊
氧化应激指标
acute myocardial infarction
percutaneous coronary intervention
Yindan Xinnaotong soft capsule
oxidative stress index
作者简介
宋锋超(1983-),男,主治医师,学士。研究方向:急危重内科常见疾病的抢救。;通讯作者:王烨,E-mail:1575322231@qq.com.
