摘要
目的研究ST段抬高心肌梗死(STEMI)患者单核细胞/高密度脂蛋白胆固醇(MHR)比值及血清肌酸激酶(CK)、心肌肌钙蛋白T(cTNT)与罪犯斑块易损特征及血流分级的关系。方法前瞻性选取榆林市第一医院心血管内科2019年1月至2021年5月收治的76例STEMI患者作为观察组,选取75例同期非STEMI患者作为对照组。比较两组患者的MHR比值和血清CK、cTNT水平;观察组患者均采用光学相干断层成像分析患者罪犯斑块易损特征和血流分级,并对比不同罪犯斑块易损特征和血流分级患者MHR比值及血清CK、cTNT水平,采用Pearson相关性检验分析患者MHR比值、血清CK、cTNT与罪犯斑块和血流分级的相关性。结果与对照组比较,观察组患者的MHR比值、血清CK、血清cTNT水平明显升高,差异均有统计学意义(P<0.05);富脂质斑块和巨噬细胞聚集患者的MHR比值明显低于胆固醇结晶和钙化患者,而血清CK、血清cTNT水平明显高于胆固醇结晶和钙化患者,差异均有统计学意义(P<0.05);STEMI患者MHR值随着TIMI血流等级的升高而升高,血清CK、cTNT水平随着TIMI血流等级升高而降低,各TIMI血流等级MHR比值和血清CK、cTNT水平比较差异均具有统计学意义(P<0.05);STEMI患者的血清CK、cTNT水平与血流分级呈负相关(P<0.05),MHR比值与血流分级呈正相关(P<0.05);STEMI患者的MHR比值、血清CK、cTNT水平与富脂质斑块、巨噬细胞聚集均呈正相关(P<0.05)。结论STEMI患者MHR比值及血清CK、cTNT与罪犯斑块易损特征及血流分级存在明显关系。
Objective To investigate the association of monocyte to high-density lipoprotein cholesterol ratio(MHR),serum creatine kinase(CK),and cardiac troponin T(cTNT)with culprit plaque characteristics and thrombolysis in myocardial infarction(TIMI)blood flow grade in patients with ST-segment elevation myocardial infarction(STEMI).Methods Seventy-six patients with STEMI in the Department of Cardiovascular Medicine of Yulin First Hospital from January 2019 to May 2021 were prospectively enrolled as the observation group,and another 75 non-STEMI patients in the same period were selected as control group.MHR ratio,serum CK,and cTNT levels were compared between the two groups.Optical coherence tomography was used to detect the characteristics and TIMI flow grade of culprit plaques in the observation group.Then the MHR ratio,CK,and cTNT levels were compared among patients with different culprit plaque characteristics and TIMI flow grade,and Pearson correlation analysis was used to verify the correlation of MHR,CK,and cTNT with flow grade of culprit plaques.Results Compared with the control group,the MHR ratio,serum CK,and serum cTNT levels in the observation group were significantly increased,with statistically significant differences(P<0.05).The MHR ratio in patients with lipid-rich plaque and macrophage aggregation was significantly lower than that in patients with cholesterol crystallization and calcification,while the serum CK and serum cTNT levels were significantly higher than those in patients with cholesterol crystallization and calcification,with statistically significant differences(P<0.05).The MHR value of STEMI patients increased with the increase of TIMI blood flow level,and the levels of serum CK and cTNT decreased with the increase of TIMI blood flow level.There was significant difference in MHR ratio,and the levels of serum CK and cTNT between the patients with different TIMI blood flow grade(P<0.05).Serum CK,and cTNT levels in STEMI patients were negatively correlated with blood flow classification(P<0.05),and MHR ratio was positively correlated with blood flow classification(P<0.05).MHR ratio,serum CK,and cTNT levels were positively correlated with lipid-rich plaques and macrophage aggregation in STEMI patients(P<0.05).Conclusion MHR ratio,serum CK,and cTNT in STEMI patients were significantly correlated with the culprit plaque characteristics and blood flow grade.
作者
朱艳
张栋
张慧
ZHU Yan;ZHANG Dong;ZHANG Hui(Department of Cardiovascular Medicine,Yulin First Hospital,Yulin 719000,Shaanxi,CHINA)
出处
《海南医学》
CAS
2022年第15期1935-1938,共4页
Hainan Medical Journal
关键词
ST段抬高心肌梗死
单核细胞/高密度脂蛋白胆固醇比值
肌酸激酶
心肌肌钙蛋白T
罪犯斑块
血流分级
ST-segment elevation myocardial infarction
Monocyte to high-density lipoprotein cholesterol ratio
Serum creatine kinase
Cardiac troponin T
Culprit plaques
Blood flow grade
作者简介
通讯作者:张慧,E-mail:1759285396@qq.com。
