摘要
多肽类抗生素(ABPs)是目前国内应用较广泛的抗生素种类之一。该类化合物不易被生物体吸收,多数以原型随粪便和尿液排出体外,可能会对环境和人类健康造成严重危害。本文综述了环境中ABPs的暴露情况及检测方法,揭示了其在环境中的迁移转化、降解特性及生态效应,同时介绍了其耐药菌和抗性基因的产生和去除技术,分析了该类抗生素环境安全性研究的发展趋势,提出ABPs的环境行为和生态效应研究应从多药联合使用方面及发生机理等进一步深入,未来应开发出更有效地ABPs抗性基因去除技术。本文为全面评估ABPs的环境安全性及有效避免或降低该类抗生素耐药性及抗性基因(ARGs)的传播提供科学依据。
Peptide antibiotics(ABPs)are one of the more widely used classes of antibiotics in China.These compounds are not easy to be absorbed by organisms,and most of them are excreted in their original form with feces and urine,which may cause serious harm to the environment and human health.In this review,we summarize the exposure to and detection of ABPs in the environment and reveal their migratory conversion,degradation characteristics and ecological effects.Meanwhile,its resistant bacteria and resistance gene generation and removal techniques are introduced,and the development trend of environmental safety research for this class of antibiotics is analyzed.It is proposed that the study of environmental behavior and ecological effects of ABPs should be further in-depth from the aspect of multidrug combination use and the occurrence mechanism,etc.,and more effective ABPs resistance gene removal techniques should be developed in the future.This paper provides a scientific basis to comprehensively evaluate the environmental safety of ABPs and the effective avoidance or reduction of antibiotic resistance and dissemination of resistance genes(ARGs)in this class.
作者
王磊
徐向月
马文瑾
霍美霞
孙磊
侯旖璇
刘海燕
林旭东
黄玲利
WANG Lei;XU Xiang-yue;MA Wen-jin;HUO Mei-xia;SUN Lei;HOU Yi-xuan;LIU Hai-yan;LIN Xu-dong;HUANG Ling-li(MOA Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products,Huazhong Agricultural University,Wuhan 430070,China;National Reference Laboratory of Veterinary Drug Residues(HZAU)and MOA Key Laboratory for Detection of Veterinary Drug Residues,Huazhong Agricultural University,Wuhan 430070,China)
出处
《中国兽药杂志》
2022年第7期81-88,共8页
Chinese Journal of Veterinary Drug
基金
“十三五”国家重点研发计划课题“抗菌药物代谢转归及环境微生物风险评估”(No.2018YTD0500301)。
关键词
多肽类抗生素
环境行为
生态效应评估
抗性基因
去除
polypeptide antibiotics
environmental behavior
ecological effect assessment
resistance gene
remove
作者简介
王磊,从事兽医药理学与毒理学方向研究;通讯作者:黄玲利。E-mail:huanglingli@webmail.hzau.edu.cn。
