摘要
伯氏疏螺旋体(Borrelia burgdorferi,Bb)是莱姆病(Lyme disease,LD)的病原体,经蜱传播,莱姆病患者的关节、心脏以及神经系统等均可受累。当患者神经系统受到感染以后,称为神经莱姆病(Lyme neuroborreliosis,LNB)。LNB患者的常见症状包括淋巴细胞性脑膜炎、颅神经炎和疼痛性神经根炎,个别患者可发展为痴呆及人格障碍。Bb感染可能与痴呆的发病机制有关。阿尔兹海默症(Alzheimer’s disease,AD)是痴呆的常见类型,其发病机制尚不完全清楚。Bb感染与AD发病机制的主流观点“淀粉样蛋白级联假说”有关,推测Bb可能与β-淀粉样蛋白(amyloid-β,Aβ)的形成有一定的联系。本文就Bb感染神经系统与痴呆发病的关系及其研究进展进行综述。
Borrelia burgdorferi(Bb)is the pathogen of Lyme disease(LD).Transmitted by ticks,the joints,heart and nervous system of patients with LD can be affected.When the patient’s nervous system is infected,it is called Lyme neuroborreliosis(LNB).The common symptoms of the patients with LNB include lymphocytic meningitis,cranial neuritis and Guillain-Barr’e syndrome,some patients can develop dementia and personality disorder.Studies have found that the infection of Bb is probably related to the pathogenesis of dementia.AD is a common type of dementia whose pathogenesis is not completely clear.At present,studies have found that Bb is related to the mainstream view of the pathogenesis of AD“amyloid cascade hypothesis”,which indicates that Bb may be related to the formation of amyloid-β(Aβ).In this review,we will discuss the relationship between the infection of the nervous system by Bb and dementia as well as the development of the latest researches.
作者
段懿
徐鑫
范雨鑫
刘玫肖
陈晶晶
曹文静
李冰雪
孔璟
周国忠
文世媛
彭莉
柳爱华
宝福凯
DUAN Yi;XU Xin;FAN Yu-xin;LIU Mei-xiao;CHEN Jing-jing;CAO Wen-jing;LI Bing-xue;KONG Jin;ZHOU Guo-zhong;WEN Shi-yuan;PENG Li;LIU Ai-hua;BAO Fu-kai(Yunnan Province Key Laboratory for Tropical Infectious Diseases in Universities,Kunming Medical University,Kunming 650500,China;Basic Medicine,Kunming Medical University;Department of Microbiology and Immunology,Kunming Medical University;Department of Biochemistry and Molecular Biology,Kunming Medical University)
出处
《中国病原生物学杂志》
CSCD
北大核心
2022年第6期730-733,共4页
Journal of Pathogen Biology
基金
国家自然科学基金资助项目(No.32060180,82160304,81860644,81560596)
云南省自然基金资助项目[2019FE001(-002)]。
关键词
伯氏疏螺旋体
阿尔兹海默症
痴呆
相关性
综述
Borrelia burgdorferi
Alzheimer’s disease
dementia
Lyme neuroborreliosis
review
作者简介
通讯作者:柳爱华,E-mail:liuaihua@kmmu.edu.cn;通讯作者:宝福凯,E-mail:baofukai@kmmu.edu.cn;段懿(2001-),男,云南腾冲人,本科在读,主要从事感染免疫的学习和研究。E-mail:3607637498@qq.com。