摘要
目的分析予以冠心病心绞痛患者参麦注射液加长效硝酸异山梨酯的疗效及对血小板聚集率的影响。方法选择2019年6月至2021年6月栾川县城关卫生院收治的冠心病心绞痛患者合计120例进行研究,结合随机数字表法将其中60例归为对照组(长效硝酸异山梨酯),60例归为观察组(除对照组用药之外加以参麦注射液),比较两组有效率,治疗前和结束治疗后的中医证候积分、心率、左室射血分数、左室舒张末内径值、左室收缩末内径值、心绞痛发作频率及持续时间和血小板聚集率及不良反应出现情况。结果观察组有效率高于对照组,差异有统计学意义(P<0.05)。治疗前,两组胸闷、胸痛、心悸不宁等中医证候积分相比,差异无统计学意义(P>0.05);治疗后,观察组胸闷、胸痛、心悸不宁等中医证候积分均低于对照组,差异有统计学意义(P<0.05)。治疗前,两组心率、左室射血分数、左室舒张末内径值及左室收缩末内径值相比,差异无统计学意义(P>0.05);治疗后,观察组心率、左室舒张末内径值及左室收缩末内径值均低于对照组,左室射血分数高出对照组,差异有统计学意义(P<0.05)。治疗前,两组心绞痛的发作频率及持续时间相比,差异无统计学意义(P>0.05);治疗后,观察组心绞痛的发作频率低于对照组,持续时间短于对照组,差异有统计学意义(P<0.05)。治疗前,两组2.5μmol/L、5μmol/L、300μmol/L诱导剂下的血小板抑制率相比,差异无统计学意义(P>0.05);治疗后,观察组2.5μmol/L、5μmol/L、300μmol/L诱导剂下的血小板抑制率均低于对照组,差异有统计学意义(P<0.05)。两组不良反应出现相比,差异无统计学意义(P>0.05)。结论予以冠心病心绞痛患者参麦注射液加长效硝酸异山梨酯疗效理想,能降低其血小板聚集率,控制其心绞痛症状,降低其中医证候积分,改善其心功能,且不良反应较少,值得采用。
Objective To analyze the efficacy of Shenmai Injection plus long-acting isosorbide nitrate in patients with coronary heart disease and angina pectoris and its effect on platelet aggregation rate.Methods A total of 120 patients with coronary heart disease and angina pectoris admitted to the Chengguan Health Hospital of Luanchuan county from June 2019 to June 2021 were selected for the study.Combined with the random number table method,60 of them were classified into the control group(long-acting isosorbide nitrate)and 60 into the observation group(except for the control group plus Shenmai injection).The effective rates,TCM syndrome scores,heart rate,left ventricular ejection fraction,left ventricular end diastolic diameter,left ventricular end systolic diameter,frequency and duration of angina pectoris,platelet aggregation rate and adverse reactions before and after treatment were compared between the two groups.Results The effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference between the two groups in the scores of traditional Chinese medicine syndromes such as chest tightness,chest pain and palpitation(P>0.05);After treatment,the TCM syndrome scores of chest tightness,chest pain and palpitation in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in heart rate,left ventricular ejection fraction,left ventricular end diastolic diameter and left ventricular end systolic diameter between the two groups(P>0.05);After treatment,the heart rate,left ventricular end diastolic diameter and left ventricular end systolic diameter in the observation group were lower than those in the control group,and the left ventricular ejection fraction was higher than that in the control group,the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in the frequency and duration of angina pectoris between the two groups(P>0.05);After treatment,the attack frequency of angina pectoris in the observation group was lower than that in the control group,and the duration was shorter than that in the control group,the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in platelet inhibition rate under 2.5μmol/L,5μmol/L,300μmol/L inducers between the two groups(P>0.05);After treatment,the platelet inhibition rate under 2.5μmol/L,5μmol/L,300μmol/L inducers in the observation group was lower than that in the control group(P<0.05).There was no significant difference in the occurrence of adverse reactions between the two groups(P>0.05).Conclusion The effect of Shenmai Injection plus long-acting isosorbide nitrate in patients with angina pectoris of coronary heart disease is ideal.It can reduce the platelet aggregation rate,control the symptoms of angina pectoris,reduce the score of traditional Chinese medicine syndromes,and improve their cardiac function,with less adverse reactions,which is worth using.
作者
赵策
ZHAO Ce(Department of general medicine,Chengguan Health Hospital,Luanchuan County,Luoyang Henan 471500,China)
出处
《临床研究》
2022年第8期118-121,共4页
Clinical Research
关键词
硝酸异山梨酯
参麦注射液
冠心病
心绞痛
血小板聚集率
isosorbide nitrate
Shenmai injection
coronary heart disease
angina pectoris
platelet aggregation rate
作者简介
赵策(1965-),男,汉族,河南栾川人,副主任医师,本科。研究方向:心脑血管疾病方面。
