摘要
With the constantly mutating of SARS-CoV-2 and the emergence of Variants of Concern(VOC),the implementation of vaccination is critically important.Existing SARS-CoV-2 vaccines mainly include inactivated,live attenuated,viral vector,protein subunit,RNA,DNA,and virus-like particle(VLP)vaccines.Viral vector vaccines,protein subunit vaccines,and mRNA vaccines may induce additional cellular or humoral immune regulations,including Th cell responses and germinal center responses,and form relevant memory cells,greatly improving their efficiency.However,some viral vector or mRNA vaccines may be associated with complications like thrombocytopenia and myocarditis,raising concerns about the safety of these COVID-19 vaccines.Here,we systemically assess the safety and efficacy of COVID-19 vaccines,including the possible complications and different effects on pregnant women,the elderly,people with immune diseases and acquired immunodeficiency syndrome(AIDS),transplant recipients,and cancer patients.Based on the current analysis,governments and relevant agencies are recommended to continue to advance the vaccine immunization process.Simultaneously,special attention should be paid to the health status of the vaccines,timely treatment of complications,vaccine development,and ensuring the lives and health of patients.In addition,available measures such as mix-and-match vaccination,developing new vaccines like nanoparticle vaccines,and optimizing immune adjuvant to improve vaccine safety and efficacy could be considered.
基金
the National Key Research and Development Program of China(Grant No.2022YFC0867500,BWS21J025,20SWAQK22 and 2020YFA0712102)
National Natural Science Foundation of China(Grant No.82151224)
Key Project of Beijing University of Chemical Technology(Grant No.XK1803-06,XK2020-02)
Fundamental Research Funds for Central Universities(Grant No.BUCTZY2022)
H&H Global Research and Technology Center(Grant No.H2021028).
作者简介
Maochen Li,contributed equally;Han Wang,contributed equally;Lili Tian,contributed equally;Zehan Pang,contributed equally;Correspondence:Lihua Song(songlihua@mail.buct.edu.cn);Correspondence:Yigang Tong(tongyigang@mail.buct.edu.cn);Correspondence:Huahao Fan(fanhuahao@mail.buct.edu.cn)。
