摘要
目的探究双氯芬酸钠栓联合奥曲肽预防经内镜逆行性胰胆管造影术(ERCP)术后胰腺炎的临床疗效。方法选取2018年1月至2021年1月于本院行ERCP治疗的56例患者作为研究对象,依据随机数字表法分为A组和B组,各28例。A组采用常规治疗方案,B组采用常规治疗方案+术前30 min使用双氯芬酸钠栓,比较两组术后胰腺炎发生情况及术前、术后3、24 h血清淀粉酶水平、临床症状与体征评分。结果B组术后胰腺炎发生率(3.57%)低于A组(28.57%),差异有统计学意义(P<0.05)。两组血清淀粉酶水平组间、时点、交互比较差异有统计学意义(P<0.05)。术后3、24 h,两组血清淀粉酶水平均高于术前,且B组低于A组,差异有统计学意义(P<0.05)。两组临床症状与体征评分组间、时点、交互比较差异有统计学意义(P<0.05);术后3、24 h,两组临床症状与体征评分均低于术前,且B组低于A组,差异有统计学意义(P<0.05)。结论双氯芬酸钠栓联合奥曲肽预防ERCP术后胰腺炎的临床疗效显著,可阻滞淀粉酶的分泌,改善患者的临床症状、体征,利于ERCP术后患者恢复,值得临床推广应用。
Objective To investigate the clinical effect of diclofenac sodium suppository combined with octreotide in the preventing of pancreatitis after endoscopic retrograde cholangiopancreatography(ERCP).Methods 56 patients treated with ERCP who were admitted to our hospital from January 2018 to January 2021 were selected as the research subjects,and they were divided into group A and group B according to the random number table method.Group A received conventional treatment,and group B received conventional treatment combined with diclofenac sodium suppository 30 minbefore operation,the incidence of postoperative pancreatitis,serum amylase levels,clinical symptoms and signs scores before operation,3 and 24 hours after operation were compared between the two groups.Results The incidence of postoperative pancreatitis in group B was 3.57%,which was lower than 28.57%in group A,and the difference was statistically significant(P<0.05).There were significant differences in serum amylase levels between the two groups,time points and interaction(P<0.05).At 3 and 24 h after operation,serum amylase levels in between groups were higher than those before operation,and group B was lower than group A,the difference was statistically significant(P<0.05).There were significant differences in the scores of clinical symptoms and signs between the two groups time points and interaction(P<0.05);at 3 and 24 h after operation,the scores of clinical symptoms and signs in between groups were lower than those before operationthe,and group B was lower than group A,the difference was statistically significant(P<0.05).Conclusion Diclofenac sodium suppository combined with octreotide has good clinical effect in preventing post ERCP pancreatitis,can block the secretion of amylase,improve the clinical symptoms and signs of patients,and facilitate the recovery of patients after ERCP,it is worthy of clinical application.
作者
习羽
钟珍玲
黄春风
李平
XI Yu;ZHONG Zhenling;HUANG Chunfeng;LI Ping(Department of Gastroenterology,Yichun Second People's Hospital,Yichun,Jiangxi,336000,China)
出处
《当代医学》
2022年第17期156-159,共4页
Contemporary Medicine
基金
宜春市科技计划(JXYC2021KSA106)。
关键词
经内镜逆行性胰胆管造影术
胰腺炎
奥曲肽
双氯芬酸钠栓
Endoscopic retrograde cholangiopancreatography
Pancreatitis
Octreotide
Diclofenac sodium suppositories
