摘要
肌少症是一种与恶性肿瘤及其治疗方式密切相关的疾病,是以进行性的全身广泛性骨骼肌质量下降和力量降低为主要特征的综合征,可导致身体残疾、生活质量下降,甚至死亡等不良预后事件的发生。肌少症可能是由年龄、营养不良、炎症、肿瘤、消耗性疾病等多种因素参与的疾病状态,而恶性肿瘤及相关化疗所引起的肌少症多与炎症反应、氧化应激、线粒体损伤等有关。本文对近年来肿瘤相关性肌少症的检测方法、发病机制、临床特征及干预措施等进行综述。
Sarcopenia is considered to be a disease closely related to the existence and treatment of malignant tumors.It is characterized by a syndrome of progressive and generalized loss of skeletal muscle mass and strength,which can lead to adverse prognostic events such as physical disability,decreased quality of life and even death.Sarcopenia may be a condition in which age,malnutrition,inflammation,tumors,wasting diseases and many other factors are involved.Sarcopenia caused by malignant tumor and related chemotherapy is mostly related to inflammatory reaction,oxidative stress,mitochondrial damage and so on.In this paper,the research progress on tumor-associated sarcopenia in recent years is reviewed from its test methods,pathogenesis,clinical features,and intervention strategies.
作者
李向阳
李凡
张树泽
焦作义
Li Xiang-Yang;Li Fan;Zhang Shu-Ze;Jiao Zuo-Yi(Department of General Surgery Ward 1,Lanzhou University Second Hospital,Lanzhou,Gansu 730030,China)
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2022年第7期739-744,共6页
Medical Journal of Chinese People's Liberation Army
基金
兰州大学第二医院“萃英科技创新”计划项目(2020QN-21)。
关键词
肌少症
肿瘤
研究进展
发病机制
sarcopenia
tumors
research progress
pathogenesis
作者简介
李向阳,硕士研究生,主要从事消化道肿瘤的临床研究;通信作者:焦作义,E-mail:jiaozy@lzu.edu.cn。
